内源性腺苷与失血性休克：咖啡因给药或戒断的影响
Endogenous adenosine and hemorrhagic shock: effects of caffeine administration or caffeine withdrawal.
作者信息
Conlay L A, Evoniuk G, Wurtman R J
机构信息
Laboratory of Neuroendocrine Regulation, Massachusetts Institute of Technology, Cambridge 02139.
出版信息
Proc Natl Acad Sci U S A. 1988 Jun;85(12):4483-5. doi: 10.1073/pnas.85.12.4483.
Abstract
Plasma adenosine concentrations doubled when rats were subjected to 90 min of profound hemorrhagic shock. Administration of caffeine (20 mg per kg of body weight), an adenosine-receptor antagonist, attenuated the hemorrhage-induced decrease in blood pressure. In contrast, chronic caffeine consumption (0.1% in drinking water), followed by a brief period of caffeine withdrawal, amplified the hypotensive response to hemorrhage. These data suggest that endogenous adenosine participates in the hypotensive response to hemorrhage and that caffeine may protect against, and caffeine withdrawal may exacerbate, this response.
摘要
当大鼠遭受90分钟的深度失血性休克时，血浆腺苷浓度翻倍。给予咖啡因（每千克体重20毫克），一种腺苷受体拮抗剂，可减轻出血引起的血压下降。相比之下，长期饮用含咖啡因的水（饮用水中含0.1%），随后短暂停用咖啡因，会放大对出血的降压反应。这些数据表明内源性腺苷参与了对出血的降压反应，并且咖啡因可能起到保护作用，而停用咖啡因可能会加剧这种反应。
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