莱菔硫烷 A-B，两种新的二聚吡咯-2-甲醛生物碱，来自于独行菜的块茎。
Lepipyrrolins A-B, two new dimeric pyrrole 2-carbaldehyde alkaloids from the tubers of Lepidium meyenii.
机构信息
School of Chemical Science and Technology, Yunnan University, Kunming 650091, People's Republic of China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
出版信息
Bioorg Chem. 2021 Jul;112:104834. doi: 10.1016/j.bioorg.2021.104834. Epub 2021 Mar 19.
Nine new pyrrole alkaloids, including two undescribed dimeric pyrrole 2‑carbaldehyde alkaloids, lepipyrrolins A-B (1-2), seven pyrrole-alkaloid derivatives, macapyrrolins D-J (3-9), along with three known ones (10-12) were isolated from the rhizomes of Lepidium meyenii. Their structures and absolute configurations were demonstrated by extensive spectroscopic data (1D, 2D NMR, HRESIMS), and calculated electronic circular dichroism (ECD) experiment. Compounds 1, 3-12 were tested for their nitric oxide inhibitory effects. Furthermore, compound 1 was evaluated for its cytotoxic activity against five human tumor cell lines (HL-60, SMMC-7221, A549, MCF-7, and SW480) in vitro, and displayed selective cytotoxicity against SMMC-7721 with IC value of 16.78 ± 0.49 μM.
从白刺的根茎中分离得到了 9 个新的吡咯生物碱，包括 2 个未被描述的二聚吡咯-2-甲醛生物碱 Lepipyrrolins A-B（1-2），7 个吡咯-生物碱衍生物 Macapyrrolins D-J（3-9），以及 3 个已知的（10-12）。通过广泛的光谱数据（1D、2D NMR、HRESIMS）和计算电子圆二色性（ECD）实验证明了它们的结构和绝对构型。测试了化合物 1、3-12 对一氧化氮抑制作用。此外，化合物 1 还在体外对 5 个人类肿瘤细胞系（HL-60、SMMC-7221、A549、MCF-7 和 SW480）进行了细胞毒性活性评估，对 SMMC-7721 表现出选择性细胞毒性，IC 值为 16.78±0.49μM。
Zotero 插件