Center for MicroElectroMechanics Systems (CMEMS), University of Minho, Campus de Azurém, 4800-058 Guimarães, Portugal.
School of Chemical Engineering and Advanced Materials, The University of Adelaide, Adelaide, SA 5000, Australia.
Adv Colloid Interface Sci. 2021 Apr;290:102380. doi: 10.1016/j.cis.2021.102380. Epub 2021 Feb 3.
Ferrite magnetic nanoparticles (FMNPs) are gaining popularity to design biosensors for high-performance clinical diagnosis. The fusion of information shows that FMNPs based biosensors require well-tuned FMNPs as detection probes to produce large and specific biological signals with minimal non-specific binding. Nevertheless, there is a noticeable lacuna of information to solve the issues related to suitable synthesis route, particle size reduction, functionalization, sensitivity towards targeted intercellular biological tiny particles, and lower signal-to-noise ratio. Therefore it allows exploring unique characteristics of FMNPs to design a suitable sensing device for intracellular measurements and diseases detection. This review focuses on the extensively used synthesis routes, their advantages and limitations, crystalline structure, functionalization, along with recent applications of FMNPs in biosensors, taking into consideration their analytical figures of merit and range of linearity. This work also addresses the current progress, key factors for sensitivity, selectivity and productivity improvement along with the challenges, future trends and perspectives of FMNPs based biosensors.
铁氧体磁性纳米粒子（FMNPs）在设计高性能临床诊断用生物传感器方面越来越受欢迎。信息融合表明，基于 FMNPs 的生物传感器需要经过精心调整的 FMNPs 作为检测探针，以产生具有最小非特异性结合的大而特定的生物信号。然而，在解决与合适的合成途径、粒径减小、功能化、对靶向细胞内生物小微粒的敏感性以及较低的信噪比相关的问题方面，仍存在明显的信息空白。因此，有必要探索 FMNPs 的独特特性，为细胞内测量和疾病检测设计合适的传感设备。本文综述了广泛使用的合成途径、它们的优点和局限性、晶体结构、功能化以及 FMNPs 在生物传感器中的最新应用，同时考虑了它们的分析性能和线性范围。本文还讨论了基于 FMNPs 的生物传感器的当前进展、提高灵敏度、选择性和生产力的关键因素以及面临的挑战、未来趋势和展望。
