MPT64 检测法快速检测结核分枝杆菌。
MPT64 assays for the rapid detection of Mycobacterium tuberculosis.
机构信息
Department of Clinical Laboratory Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China.
Department of Clinical Medicine, The Third Clinical School of Guangzhou Medical University, Guangzhou, 511436, China.
出版信息
BMC Infect Dis. 2021 Apr 10;21(1):336. doi: 10.1186/s12879-021-06022-w.
BACKGROUND
Tuberculosis (TB) is a serious infectious disease caused by Mycobacterium tuberculosis (MTB). An estimated 1.7 billion people worldwide are infected with Mycobacterium tuberculosis (LTBI) during the incubation period without any obvious symptoms. Because of MTB's high infection and mortality rates, there is an urgent need to develop a fast, portable, and sensitive diagnostic technology for its detection.
METHODS
We included research from PubMed, Cochrane Library, Web of Science, and Embase and extracted the data. MetaDisc and STATA were used to build forest plots, Deek's funnel plot, Fagan plot, and bivariate boxplot for analysis.
RESULTS
Forty-six articles were analyzed, the results of which are as follows: sensitivity and specificity were 0.92 (0.91-0.93) and 0.95 (0.94-0.95) respectively. The NLR and PLR were 0.04 (95% CI 0.03-0.07) and 25.32 (95% CI 12.38-51.78) respectively. DOR was 639.60 (243.04-1683.18). The area under the SROC curve (AUC) was 0.99.
CONCLUSIONS
MPT64 exhibits good diagnostic efficiency for MTB. There is no obvious heterogeneity between the three commercial kits.
背景
结核病（TB）是一种由结核分枝杆菌（MTB）引起的严重传染病。据估计，全球有 17 亿人在潜伏期感染了结核分枝杆菌（LTBI），但没有任何明显症状。由于 MTB 的高感染率和死亡率，迫切需要开发一种快速、便携、敏感的检测诊断技术。
方法
我们纳入了来自 PubMed、Cochrane 图书馆、Web of Science 和 Embase 的研究，并提取了数据。使用 MetaDisc 和 STATA 构建森林图、Deek 漏斗图、Fagan 图和双变量箱线图进行分析。
结果
分析了 46 篇文章，结果如下：灵敏度和特异性分别为 0.92（0.91-0.93）和 0.95（0.94-0.95）。NLR 和 PLR 分别为 0.04（95% CI 0.03-0.07）和 25.32（95% CI 12.38-51.78）。DOR 为 639.60（243.04-1683.18）。SROC 曲线下面积（AUC）为 0.99。
结论
MPT64 对 MTB 具有良好的诊断效率。三种商业试剂盒之间没有明显的异质性。
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