Ferstl Philip, Trebicka Jonel
Department for Internal Medicine I, University Hospital, Goethe University, Theodor-Stern-Kai 7, Frankfurt am Main 60590, Germany.
Department for Internal Medicine I, University Hospital, Goethe University, Theodor-Stern-Kai 7, Frankfurt am Main 60590, Germany; European Foundation for the Study of Chronic Liver Failure, Travesera de Gracia 11, 08021 Barcelona, Spain.
Clin Liver Dis. 2021 May;25(2):419-430. doi: 10.1016/j.cld.2021.01.009. Epub 2021 Mar 10.
Liver cirrhosis is a major healthcare problem. Acute decompensation, and in particular its interplay with dysfunction of other organs, is responsible for the majority of deaths in patients with cirrhosis. Acute decompensation has different courses, from stable decompensated cirrhosis over unstable decompensated cirrhosis to pre-acute-on-chronic liver failure and finally acute-on-chronic liver failure, a syndrome with high short-term mortality. This review focuses on the recent developments in the field of acute decompensation and acute-on-chronic liver failure.
肝硬化是一个重大的医疗保健问题。急性失代偿，尤其是其与其他器官功能障碍的相互作用，是肝硬化患者死亡的主要原因。急性失代偿有不同的病程，从稳定的失代偿性肝硬化到不稳定的失代偿性肝硬化，再到慢性肝衰竭急性发作前期，最终发展为慢性肝衰竭急性发作，这是一种短期死亡率很高的综合征。本综述重点关注急性失代偿和慢性肝衰竭急性发作领域的最新进展。
