Lim Jungeun, Ching Hanna, Yoon Jeong-Kee, Jeon Noo Li, Kim YongTae
School of Mechanical and Aerospace Engineering, Seoul National University, Seoul, 08826, Republic of Korea.
George W, Woodruff School of Mechanical Engineering, Georgia Institute of Technology, North Ave NW, Atlanta, GA, 30332, USA.
Nano Converg. 2021 Apr 13;8(1):12. doi: 10.1186/s40580-021-00261-y.
Recent developments of organoids engineering and organ-on-a-chip microfluidic technologies have enabled the recapitulation of the major functions and architectures of microscale human tissue, including tumor pathophysiology. Nevertheless, there remain challenges in recapitulating the complexity and heterogeneity of tumor microenvironment. The integration of these engineering technologies suggests a potential strategy to overcome the limitations in reconstituting the perfusable microvascular system of large-scale tumors conserving their key functional features. Here, we review the recent progress of in vitro tumor-on-a-chip microfluidic technologies, focusing on the reconstruction of microvascularized organoid models to suggest a better platform for personalized cancer medicine.
类器官工程和芯片器官微流控技术的最新进展已能够重现微观尺度人体组织的主要功能和结构，包括肿瘤病理生理学。然而，在重现肿瘤微环境的复杂性和异质性方面仍然存在挑战。这些工程技术的整合提出了一种潜在策略，以克服在重建具有关键功能特征的大规模肿瘤的可灌注微血管系统方面的局限性。在此，我们综述了体外芯片肿瘤微流控技术的最新进展，重点关注微血管化类器官模型的重建，以提出一个更好的个性化癌症医学平台。
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