病毒合并感染是否为下呼吸道严重感染的危险因素？一项回顾性观察研究。
Is viral coinfection a risk factor for severe lower respiratory tract infection? A retrospective observational study.
机构信息
Department of Pediatric Pulmonology, Gazi Yaşargil Gynecology, Child Health, and Diseases Training and Research Hospital, University of Health Sciences, Diyarbakır, Turkey.
Department of Pediatric Pulmonology, Ege University Medical Faculty, Ege University Children Hospital, Izmir, Turkey.
出版信息
Pediatr Pulmonol. 2021 Jul;56(7):2195-2203. doi: 10.1002/ppul.25422. Epub 2021 Apr 26.
Abstract
OBJECTIVE
To determine whether viral coinfection is a risk for severe lower respiratory tract infection (LRTI).
WORKING HYPOTHESIS
Children with viral coinfection had a higher risk for admission to the intensive care unit (ICU) than those with a single virus infection.
STUDY DESIGN
Retrospective, observational study for 10 years.
PATIENT-SUBJECT SELECTION: Children between 1 and 60 months of age hospitalized with LRTI.
摘要
目的
确定病毒合并感染是否会增加下呼吸道感染（LRTI）的严重程度。
工作假说
与单纯病毒感染患儿相比，病毒合并感染患儿入住重症监护病房（ICU）的风险更高。
研究设计
回顾性观察性研究，为期 10 年。
患者/受试者选择：年龄在 1 至 60 个月之间、因 LRTI 住院的儿童。
相似文献
1
Is viral coinfection a risk factor for severe lower respiratory tract infection? A retrospective observational study.病毒合并感染是否为下呼吸道严重感染的危险因素？一项回顾性观察研究。
Pediatr Pulmonol. 2021 Jul;56(7):2195-2203. doi: 10.1002/ppul.25422. Epub 2021 Apr 26.
2
Comparison of Clinical, Demographic Features, and Costs in Respiratory Syncytial Virus, Rhinovirus, and Viral Co-infections in Children Hospitalized with Viral Infections of the Lower Respiratory Tract.比较下呼吸道病毒感染住院患儿中呼吸道合胞病毒、鼻病毒和病毒合并感染的临床、人口统计学特征和成本。
Jpn J Infect Dis. 2022 Mar 24;75(2):164-168. doi: 10.7883/yoken.JJID.2021.328. Epub 2021 Aug 31.
3
The burden of single virus and viral coinfections on severe lower respiratory tract infections among preterm infants: a prospective birth cohort study in Brazil.单一病毒及病毒合并感染对早产儿严重下呼吸道感染的影响：巴西一项前瞻性出生队列研究
Pediatr Infect Dis J. 2014 Oct;33(10):997-1003. doi: 10.1097/INF.0000000000000349.
4
Severity of Respiratory Syncytial Virus Lower Respiratory Tract Infection With Viral Coinfection in HIV-Uninfected Children.未感染HIV儿童呼吸道合胞病毒下呼吸道感染合并病毒感染的严重程度
Clin Infect Dis. 2017 Feb 15;64(4):443-450. doi: 10.1093/cid/ciw756.
5
The burden of viral lower respiratory tract infections during the neonatal period: six-year experience at a tertiary referral hospital.新生儿期病毒下呼吸道感染的负担：一家三级转诊医院的六年经验。
Croat Med J. 2022 Aug 31;63(4):343-351. doi: 10.3325/cmj.2022.63.343.
6
A Retrospective Cohort Study on Infant Respiratory Tract Infection Hospitalizations and Recurrent Wheeze and Asthma Risk: Impact of Respiratory Syncytial Virus.一项关于婴儿呼吸道感染住院和反复喘息及哮喘风险的回顾性队列研究：呼吸道合胞病毒的影响。
J Infect Dis. 2022 Aug 12;226(Suppl 1):S55-S62. doi: 10.1093/infdis/jiac141.
7
Viral Co-Infections in Pediatric Patients Hospitalized with Lower Tract Acute Respiratory Infections.因下呼吸道急性呼吸道感染住院的儿科患者中的病毒合并感染
PLoS One. 2015 Sep 2;10(9):e0136526. doi: 10.1371/journal.pone.0136526. eCollection 2015.
8
An investigation into the prevalence and outcome of patients admitted to a pediatric intensive care unit with viral respiratory tract infections in Cape Town, South Africa.对南非开普敦一家儿科重症监护病房因病毒性呼吸道感染入院的患者的患病率和结局进行调查。
Pediatr Crit Care Med. 2012 Sep;13(5):e275-81. doi: 10.1097/PCC.0b013e3182417848.
9
Etiology, seasonality, and clinical characterization of viral respiratory infections among hospitalized children in Beirut, Lebanon.黎巴嫩贝鲁特住院儿童病毒性呼吸道感染的病因、季节性和临床特征
J Med Virol. 2016 Nov;88(11):1874-81. doi: 10.1002/jmv.24544. Epub 2016 May 19.
10
Human respiratory syncytial virus: prevalence, viral co-infections and risk factors for lower respiratory tract infections in children under 5 years of age at a general hospital in the Democratic Republic of Congo.人类呼吸道合胞病毒：刚果民主共和国一家综合医院5岁以下儿童的患病率、病毒合并感染及下呼吸道感染的危险因素
J Med Microbiol. 2018 Apr;67(4):514-522. doi: 10.1099/jmm.0.000713. Epub 2018 Mar 6.
引用本文的文献
1
Risk factors for severe lower respiratory tract infection among children under 5 years of age hospitalized with respiratory syncytial virus.呼吸道合胞病毒住院的5岁以下儿童严重下呼吸道感染的危险因素。
Eur J Clin Microbiol Infect Dis. 2025 Jun 25. doi: 10.1007/s10096-025-05191-9.
2
Pathogenesis of influenza and SARS-CoV-2 co-infection at the extremes of age: decipher the ominous tales of immune vulnerability.流感与严重急性呼吸综合征冠状病毒2（SARS-CoV-2）在老年和幼年人群中合并感染的发病机制：解读免疫脆弱性的不祥故事
Adv Biotechnol (Singap). 2025 Jan 21;3(1):5. doi: 10.1007/s44307-025-00057-9.
3
Analysis of a Cohort of 165 Pediatric Patients with Human Bocavirus Infection and Comparison between Mono-Infection and Respiratory Co-Infections: A Retrospective Study.165例人博卡病毒感染儿科患者队列分析及单一感染与呼吸道合并感染的比较：一项回顾性研究
Pathogens. 2024 Jan 6;13(1):55. doi: 10.3390/pathogens13010055.
4
Human Bocavirus in Childhood: A True Respiratory Pathogen or a "Passenger" Virus? A Comprehensive Review.儿童人博卡病毒：真正的呼吸道病原体还是“过客”病毒？全面综述。
Microorganisms. 2023 May 9;11(5):1243. doi: 10.3390/microorganisms11051243.
5
Human bocavirus-1 screening in infants with acute lower respiratory tract infection.人博卡病毒-1 筛查在急性下呼吸道感染的婴儿。
J Int Med Res. 2021 Aug;49(8):3000605211027739. doi: 10.1177/03000605211027739.
本文引用的文献
1
Epidemiological and clinical characteristics of the COVID-19 epidemic in Brazil.巴西 COVID-19 疫情的流行病学和临床特征。
Nat Hum Behav. 2020 Aug;4(8):856-865. doi: 10.1038/s41562-020-0928-4. Epub 2020 Jul 31.
2
Respiratory viruses: What is their role in acute exacerbations in children with cystic fibrosis?呼吸道病毒：它们在儿童囊性纤维化急性加重中的作用是什么？
Pediatr Pulmonol. 2020 Jul;55(7):1646-1652. doi: 10.1002/ppul.24750. Epub 2020 Mar 30.
3
Risk Factors for Influenza Virus Related Severe Lower Respiratory Tract Infection in Children.儿童流感相关重症下呼吸道感染的危险因素。
Pediatr Infect Dis J. 2019 Nov;38(11):1090-1095. doi: 10.1097/INF.0000000000002447.
4
Severity of Respiratory Syncytial Virus Lower Respiratory Tract Infection With Viral Coinfection in HIV-Uninfected Children.未感染HIV儿童呼吸道合胞病毒下呼吸道感染合并病毒感染的严重程度
Clin Infect Dis. 2017 Feb 15;64(4):443-450. doi: 10.1093/cid/ciw756.
5
Viral bronchiolitis.病毒性细支气管炎
Lancet. 2017 Jan 14;389(10065):211-224. doi: 10.1016/S0140-6736(16)30951-5. Epub 2016 Aug 20.
6
Bronchiolitis: Analysis of 10 consecutive epidemic seasons.细支气管炎：连续10个流行季节的分析
Pediatr Pulmonol. 2016 Dec;51(12):1330-1335. doi: 10.1002/ppul.23476. Epub 2016 May 26.
7
Respiratory viral coinfection and disease severity in children: A systematic review and meta-analysis.儿童呼吸道病毒合并感染与疾病严重程度：一项系统评价与荟萃分析。
J Clin Virol. 2016 Jul;80:45-56. doi: 10.1016/j.jcv.2016.04.019. Epub 2016 Apr 30.
8
Bacterial and viral co-infections complicating severe influenza: Incidence and impact among 507 U.S. patients, 2013-14.2013 - 2014年美国507例患者中，细菌和病毒合并感染使重症流感复杂化：发病率及影响
J Clin Virol. 2016 Jul;80:12-9. doi: 10.1016/j.jcv.2016.04.008. Epub 2016 Apr 14.
9
Risk factors for mortality from acute lower respiratory infections (ALRI) in children under five years of age in low and middle-income countries: a systematic review and meta-analysis of observational studies.低收入和中等收入国家五岁以下儿童急性下呼吸道感染（ALRI）死亡的危险因素：观察性研究的系统评价和荟萃分析
PLoS One. 2015 Jan 30;10(1):e0116380. doi: 10.1371/journal.pone.0116380. eCollection 2015.
10
Is virus coinfection a predictor of severity in children with viral respiratory infections?病毒合并感染是否是病毒性呼吸道感染儿童病情严重程度的预测指标？
Clin Microbiol Infect. 2015 Mar;21(3):264.e1-6. doi: 10.1016/j.cmi.2014.08.024. Epub 2014 Oct 29.
Zotero 插件