Morelli Jacopo, Rossi Sophie, Fuchs Boris, Richard Emmanuelle, Barros Daniela S B, Küker Susanne, Arnemo Jon M, Evans Alina L
Department of Forestry and Wildlife Management, Inland Norway University of Applied Sciences, Koppang, Norway.
Wildlife Diseases Unit, French Agency for Biodiversity, Gap, France.
Front Vet Sci. 2021 Mar 29;8:655345. doi: 10.3389/fvets.2021.655345. eCollection 2021.
Three medetomidine-based drug protocols were compared by evaluating time courses, reliability and physiological effects in wild boars. A total of 21 cage-trapped wild boars () were immobilized using one of the following drug combinations; MTZ: medetomidine (0.2 mg/kg) + tiletamine-zolazepam (2.0 mg/kg), MK: medetomidine (0.15 mg/kg) + ketamine (5 mg/kg), and MKB: medetomidine (0.1 mg/kg) + ketamine (5.0 mg/kg) + butorphanol (0.2 mg/kg). Induction time, recovery time, and physiological variables were recorded and arterial blood gas analysis measured twice, before and after 15 min of oxygen supplementation (0.5-1.0 L/min). For reversal, 4 mg of atipamezole per mg of medetomidine was administered intramuscularly. The boars recovered in the cage and were released once ataxia resolved. The MK group had significantly longer recovery times (mean 164 min ± 79 SD) compared to the other groups. MKB elicited longer and incomplete induction compared to the other groups (mean induction time 20 min ± 10 SD), decreasing the efficiency of the capture and increasing the risk of hyperthermia. Both ketamine-based protocols required additional ketamine intramuscularly to prolong the anesthesia after 20-40 min from induction. Agreement between the pulse oximeter and the blood gas analyzer was low, with the pulse oximeter underestimating the real values of arterial oxyhemoglobin saturation, particularly at higher readings. Mild acute respiratory acidosis (PaCO 45-60 mmHg) and mild to moderate hypoxemia (PaO 69-80 mmHg) occurred in most boars, regardless of the treatment group but especially in the MKB group. The acid-base status improved and hypoxemia resolved in all boars during oxygen supplementation, with the PaO rising above the physiological reference range (81.6-107.7 mmHg) in many individuals. MK and MKB induced safe and reliable immobilization of wild boars for at least 20 min. Supplemental oxygen delivery is recommended in order to prevent hypoxemia in wild boars immobilized with the protocols used in the present study. Long and ataxic recoveries occurred in most animals, regardless of the protocol, but especially in the MKB group.
通过评估时间进程、可靠性和生理效应,对三种基于美托咪定的药物方案在野猪身上进行了比较。总共21只笼养捕获的野猪()使用以下药物组合之一进行麻醉;MTZ:美托咪定(0.2毫克/千克)+替来他明-唑拉西泮(2.0毫克/千克),MK:美托咪定(0.15毫克/千克)+氯胺酮(5毫克/千克),以及MKB:美托咪定(0.1毫克/千克)+氯胺酮(5.0毫克/千克)+布托啡诺(0.2毫克/千克)。记录诱导时间、恢复时间和生理变量,并在补充氧气(0.5 - 1.0升/分钟)15分钟前后进行两次动脉血气分析测量。为了进行苏醒,每毫克美托咪定肌肉注射4毫克阿替美唑。野猪在笼中恢复,一旦共济失调消失就被放归。与其他组相比,MK组的恢复时间明显更长(平均164分钟±79标准差)。与其他组相比,MKB组诱导时间更长且不完全(平均诱导时间20分钟±10标准差),降低了捕获效率并增加了体温过高的风险。两种基于氯胺酮 的方案在诱导后20 - 40分钟需要额外肌肉注射氯胺酮以延长麻醉时间。脉搏血氧仪与血气分析仪之间的一致性较低,脉搏血氧仪低估了动脉血氧血红蛋白饱和度的实际值,尤其是在较高读数时。大多数野猪出现轻度急性呼吸性酸中毒(动脉血二氧化碳分压45 - 60毫米汞柱)和轻度至中度低氧血症(动脉血氧分压69 - 80毫米汞柱),无论治疗组如何,但在MKB组中尤为明显。在补充氧气期间,所有野猪的酸碱状态均得到改善且低氧血症得到缓解,许多个体的动脉血氧分压升至生理参考范围(81.6 - 107.7毫米汞柱)以上。MK和MKB诱导野猪安全可靠地麻醉至少20分钟。建议提供补充氧气,以防止使用本研究中所用方案麻醉的野猪出现低氧血症。大多数动物出现长时间共济失调性恢复,无论方案如何,但在MKB组中尤为明显。