冻融胚胎与新鲜胚胎在体外受精周期中临床疗效的系统评价。

A systematic review of clinical efficacy of frozen-thawed embryos and fresh embryos in in-vitro fertilization cycles.

机构信息

Department of Gynecology and Obstetrics, Wuxi No.2 Chinese Medicine Hospital, Wuxi, China.

出版信息

Cryobiology. 2021 Jun;100:19-25. doi: 10.1016/j.cryobiol.2021.04.004. Epub 2021 Apr 16.

DOI:10.1016/j.cryobiol.2021.04.004

PMID:33872610

Abstract

BACKGROUND

Frozen-thawed embryo (FTE) and fresh embryo (FE) transfer are two common strategies in vitro fertilization (IVF), while the results and findings still vary among studies.

METHODS

We searched multiple databases for relevant studies comparing the clinical effects of FTE and FE. Meta-analyses were conducted with Review Manager 5.0 to assess the efficacy among included articles. We also analyzed the risk of bias for the reports.

RESULTS

Nine studies eventually met the inclusion criteria from 2010 to 2018, and 11396 patients were included. The meta-analyses indicated no significant difference in biochemical pregnancy, clinical pregnancy and ongoing pregnancy rates. Meanwhile, the implantation rate and live birth rate in frozen-thawed embryos were much higher than those of fresh embryo. The birth weight in the frozen-thawed ET group was greater than that of the FE group, and the low birth weight rate in FTE was lower than FE group.

CONCLUSION

Our findings suggested a trend toward favouring frozen-thawed FTE might be a preferred transfer strategy for patients with IVF.

摘要

背景

冻融胚胎（FTE）和新鲜胚胎（FE）移植是体外受精（IVF）中两种常见的策略，然而，不同研究的结果和发现仍存在差异。

方法

我们检索了多个数据库，以寻找比较 FTE 和 FE 临床效果的相关研究。使用 Review Manager 5.0 进行荟萃分析，以评估纳入文章中的疗效。我们还分析了报告的偏倚风险。

结果

最终，我们从 2010 年至 2018 年的研究中筛选出了 9 项符合纳入标准的研究，共纳入了 11396 名患者。荟萃分析表明，生化妊娠、临床妊娠和持续妊娠率均无显著差异。同时，冻融胚胎的种植率和活产率明显高于新鲜胚胎，冻融胚胎移植组的出生体重大于新鲜胚胎组，而冻融胚胎组的低出生体重率低于新鲜胚胎组。