Dipartimento di Chimica, Università degli Studi di Milano, via C. Golgi, 19, 20133-Milano,Italy.
Curr Med Chem. 2022;29(2):329-357. doi: 10.2174/0929867328666210419135519.
Conducting polymers are an outstanding class of materials characterized by electroconductive properties that make them good candidates for applications in several sectors. Among them, polyaniline (PANI) is unique for its extraordinary ability to conduct electricity, biocompatibility, and low toxicity. In spite of its surprising features, to date, PANI has not found application in practical uses due to its low solubility and processability. In order to overcome these limitations, different approaches have been developed, such as polymer grafting processes, PANI-based composites, and blends preparation. The present review describes the most recent advances on PANI applications in biomedical fields, such as antioxidant, antimicrobial and antivirus activity, drug delivery, cancer therapy, etc. In this article, synthetic procedures are also reported which are crucial for the realization of more innovative materials in the future.
导电聚合物是一类杰出的材料,具有导电性,使其成为多个领域应用的良好候选材料。其中,聚苯胺 (PANI) 因其非凡的导电能力、生物相容性和低毒性而独具特色。尽管具有惊人的特性,但迄今为止,由于其低溶解度和可加工性,PANI 尚未在实际用途中得到应用。为了克服这些限制,已经开发了不同的方法,例如聚合物接枝过程、基于 PANI 的复合材料和共混物制备。本综述描述了 PANI 在生物医学领域的最新应用进展,例如抗氧化、抗菌和抗病毒活性、药物输送、癌症治疗等。本文还报道了合成程序,这些程序对于未来实现更具创新性的材料至关重要。