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肾移植的长期感染性并发症。

Long-Term Infectious Complications of Kidney Transplantation.

机构信息

Division of Nephrology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Division of Organ Transplantation, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

出版信息

Clin J Am Soc Nephrol. 2022 Feb;17(2):286-295. doi: 10.2215/CJN.15971020. Epub 2021 Apr 20.

Abstract

Infections remain a common complication of solid-organ transplantation. Most infections in the first month after transplant are typically health care-associated infections, whereas late infections, beyond 6-12 months, are community-acquired infections. Opportunistic infections most frequently present in the first 12 months post-transplant and can be modulated on prior exposures and use of prophylaxis. In this review, we summarize the current epidemiology of postkidney transplant infections with a focus on key viral (BK polyomavirus, cytomegalovirus, Epstein-Barr virus, and norovirus), bacterial (urinary tract infections and colitis), and fungal infections. Current guidelines for safe living post-transplant are also summarized. Literature supporting prophylaxis and vaccination is also provided.

摘要

感染仍然是实体器官移植的常见并发症。移植后第一个月的大多数感染通常是与医疗保健相关的感染,而 6-12 个月后的迟发性感染是社区获得性感染。机会性感染在移植后 12 个月内最常发生,并且可以根据既往暴露和预防用药情况进行调节。在这篇综述中,我们总结了肾移植后感染的当前流行病学情况,重点介绍了关键的病毒(BK 多瘤病毒、巨细胞病毒、Epstein-Barr 病毒和诺如病毒)、细菌(尿路感染和结肠炎)和真菌感染。还总结了移植后安全生活的现行指南。同时也提供了支持预防和疫苗接种的文献。

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本文引用的文献

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