光响应从球形到纳米管状组装体的转变：使用大环阳离子双子型两亲物的抗癌药物递送。
Photoresponsive transformation from spherical to nanotubular assemblies: anticancer drug delivery using macrocyclic cationic gemini amphiphiles.
机构信息
Indian Institute of Technology Guwahati, Chemistry, Guwahati, Assam, India.
Calcutta University, Zoology, Kolkata, West Bengal, India.
出版信息
Chem Commun (Camb). 2021 May 11;57(38):4646-4649. doi: 10.1039/d1cc01468d.
We developed NIR-light-responsive macrocyclic cationic gemini amphiphiles, one of which displayed various favorable properties of lipids. The NIR-light-mediated cleavage of the strained dioxacycloundecine ring led to the conversion of the spherical to a nanotubular self-assembly in the aqueous medium. This photo-mediated transformation from the spherical to nanotubular self-assembly resulted in the release of encapsulated hydrophobic anticancer drug molecule doxorubicin (Dox) in a controlled manner. The potent cationic gemini amphiphile also displayed lower cytotoxicity and efficient NIR-light-mediated Dox release efficacy to cancerous cells.
我们开发了对近红外光响应的大环阳离子双子两亲分子，其中一种显示出脂质的各种优良性质。受应变的二氧杂环十一烷环的近红外光介导裂解导致在水介质中从球形到纳米管状自组装的转化。这种从球形到纳米管状自组装的光介导转变导致封装的疏水性抗癌药物阿霉素（Dox）以受控方式释放。有效的阳离子双子两亲分子还表现出较低的细胞毒性和有效的近红外光介导的阿霉素（Dox）释放功效对癌细胞。
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