Donner A, Hauck W
Department of Epidemiology and Biostatistics, University of Western Ontario, London, Canada.
Biometrics. 1988 Jun;44(2):369-78.
A new estimator of a common odds ratio is proposed for case-control studies of familial aggregation. The proposed estimator is a modification to the usual Mantel-Haenszel estimator that relies on an empirical adjustment for the within-family clustering which is typical of such designs. A simulation study shows that the estimator tends to have smaller mean squared error than the unmodified Mantel-Haenszel estimator under conditions likely to arise in practice. The construction of confidence intervals is also discussed.
针对家族聚集性的病例对照研究，提出了一种新的共同比值比估计量。所提出的估计量是对常用的Mantel-Haenszel估计量的一种修正，它依赖于对这类设计中典型的家庭内部聚类进行经验调整。一项模拟研究表明，在实际可能出现的条件下，该估计量的均方误差往往比未修正的Mantel-Haenszel估计量更小。还讨论了置信区间的构建。
