Department of Respiratory and Critical Care Medicine, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Jie Fang Road, Han Kou District, Wu Han, 1095430030, HuBei Province, China.
Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue 1095, Wuhan, 430030, China.
BMC Pulm Med. 2021 Apr 27;21(1):138. doi: 10.1186/s12890-021-01504-8.
Pulmonary mucormycosis caused by Mucorales is a highly lethal invasive fungal infection usually found in immunocompromised patients. Isolated pulmonary mucormycosis in immunocompetent patients is very rare. Here, we present a case of a 32-year-old male who developed pulmonary mucormycosis without any known immunodeficiency.
The patient presented to our hospital because of cough and chest pain along with blood in the sputum. He was first treated for community-acquired pneumonia until bronchoalveolar lavage fluid culture confirmed the growth of Absidia. His symptoms were relieved with the use of amphotericin B, and he eventually recovered. We also provide a systematic review of relevant literature to summarize the characteristics of pulmonary mucormycosis in immunocompetent patients.
Pulmonary mucormycosis has variable clinical presentations and is difficult to identify. Due to its high fatality rate, clinicians should make judgements regarding suspected cases correctly and in a timely manner to avoid misdiagnosis and delayed treatment.
毛霉目引起的肺部毛霉菌病是一种高度致命的侵袭性真菌感染，通常发生在免疫功能低下的患者中。免疫功能正常的患者中孤立性肺部毛霉菌病非常罕见。在这里，我们报告了一例 32 岁男性患者，他患有肺部毛霉菌病，但没有任何已知的免疫缺陷。
该患者因咳嗽、胸痛和痰中带血到我院就诊。他最初被诊断为社区获得性肺炎，直到支气管肺泡灌洗液培养确认了棘孢木霉的生长。他使用两性霉素 B 治疗后症状得到缓解，最终康复。我们还对相关文献进行了系统回顾，以总结免疫功能正常患者肺部毛霉菌病的特征。
肺部毛霉菌病的临床表现多样，难以识别。由于其高死亡率，临床医生应及时正确地对疑似病例做出判断，避免误诊和治疗延误。
