Association Analysis of Polymorphisms in and with Mild Cognitive Impairment in Elderly Carrying Allele.

BACKGROUND

Apolipoprotein () is recognized as an independent risk factor for mild cognitive impairment (MCI). However, not everyone with the ε4 allele develops MCI, suggesting that other susceptibility genes exist. This study aimed to identify MCI susceptibility genes, including , and , in elderly Han Chinese and to verify their association with ε4 allele in MCI onset.

METHODS

To determine whether polymorphisms in (rs6733839, rs7561528), (rs2228479), (rs10164112), and (rs6859) occurred in elderly MCI patients carrying allele, we carried out a case-control study including 285 MCI patients and 326 healthy controls.

RESULTS

Statistically significant differences in the proportion of carriers, and BESCI, ADAS-cog, and CNT scores existed between the NC and MCI groups (all < 0.01). Frequencies of the rs10164112 T and rs6859 A alleles were significantly higher in the latter than in the former ( = 0.01; 0.029). However, no significant differences in allele and genotype distribution of (rs6733839, rs7561528) and (rs2228479) existed between samples in our two groups (all > 0.05). When stratified by status (carriers/non-carriers), genotype frequencies of rs7561528, rs10164112, and rs6859 among the four groups (NCε4+, NCε4-, MCIε4+, MCIε4-) were significantly different. Additionally, our results suggest a significant association between MCI and rs7561528, rs10164112, and rs6859 (all <0.05) in elderly carriers.

CONCLUSION

This suggests that among the Han Chinese, MCI in elderly carriers may be related to the (rs7561528), (rs10164112) and (rs6859). Genotype AA of rs7561528 and TT of rs10164112 might be protective factors against MCI in elderly carriers.