膀胱癌中血栓反应蛋白-3、4 和 5 的病理意义和预后作用。
Pathological Significance and Prognostic Roles of Thrombospondin-3, 4 and 5 in Bladder Cancer.
机构信息
Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
出版信息
In Vivo. 2021 May-Jun;35(3):1693-1701. doi: 10.21873/invivo.12429.
BACKGROUND/AIM: The pathological significance of thrombospondin (TSP)-1 and -2 in bladder cancer (BC) is well-known whereas that of TSP-3, 4 and 5 remains unclear. Our aim is to clarify the pathological significance and prognostic roles of TSP-3 to 5 expression in BC patients.
PATIENTS AND METHODS
TSP-3 to 5 expression, proliferation index (PI), apoptotic index (AI) and microvessel density (MVD) were evaluated in 206 BC patients by immunohistochemical techniques.
RESULTS
TSP-5 expression was positively associated with grade, T stage, metastasis, and worse prognosis. PI in TSP-5-positive tissues was significantly higher compared to negative tissues. In contrast, AI in TSP-5-positive tissues was significantly lower compared to negative tissues. Expressions of TSP-3 and 4 were not associated with any clinicopathological features, survival, PI, or AI.
CONCLUSION
TSP-5 plays important roles in malignant behavior via cell survival regulation whereas the pathological significance of TSP-3 and TSP-4 in BC might be minimal.
背景/目的：血栓反应蛋白（TSP）-1 和 -2 在膀胱癌（BC）中的病理学意义已得到充分证实，而 TSP-3、-4 和 -5 的病理学意义尚不清楚。我们旨在阐明 TSP-3 至 -5 在 BC 患者中的表达的病理学意义和预后作用。
患者和方法
通过免疫组织化学技术评估了 206 例 BC 患者的 TSP-3 至 -5 表达、增殖指数（PI）、凋亡指数（AI）和微血管密度（MVD）。
结果
TSP-5 表达与分级、T 分期、转移和预后不良呈正相关。TSP-5 阳性组织的 PI 明显高于阴性组织。相比之下，TSP-5 阳性组织的 AI 明显低于阴性组织。TSP-3 和 4 的表达与任何临床病理特征、生存、PI 或 AI 均无相关性。
结论
TSP-5 通过细胞存活调控在恶性行为中发挥重要作用，而 TSP-3 和 TSP-4 在 BC 中的病理学意义可能较小。
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