锰对过氧化苯甲酰/Cu2+依赖性脂质过氧化的抑制作用。

Inhibition of benzoyl peroxide/Cu2+-dependent lipid peroxidation by manganese.

Tsujimoto Y, Nagashima K, Yamazaki M, Furuyama S

Department of Endodontics, Nihon University School of Dentistry, Matsudo, Chiba, Japan.

Int J Biochem. 1988;20(6):591-4. doi: 10.1016/0020-711x(88)90097-3.

Abstract

Formation of peroxides by benxoyl peroxide (BPO) and CuCl2 was examined in the human red blood cell ghost. 2. Amounts of peroxides formed increased with the amount of the ghost solution added. 3. Of all the cations tested only manganese ion inhibited the formation of peroxides in BPO-CuCl2 reaction system. 4. The formation of peroxides was inhibited approx. 50% with 0.4 microM manganese. 5. The inhibitory manner of manganese was non-competitive against copper.

摘要

在人红细胞血影中检测了过氧化苯甲酰（BPO）和氯化铜（CuCl2）形成过氧化物的情况。2. 形成的过氧化物量随着添加的血影溶液量的增加而增加。3. 在所有测试的阳离子中，只有锰离子在BPO-CuCl2反应体系中抑制过氧化物的形成。4. 0.4微摩尔锰可使过氧化物的形成受到约50%的抑制。5. 锰的抑制方式对铜而言是非竞争性的。