纤维蛋白封闭剂与腋窝淋巴病变：23项临床随机试验的系统评价与Meta分析

Fibrin Sealants and Axillary Lymphatic Morbidity: A Systematic Review and Meta-Analysis of 23 Clinical Randomized Trials.

作者信息

Gasparri Maria Luisa, Kuehn Thorsten, Ruscito Ilary, Zuber Veronica, Di Micco Rosa, Galiano Ilaria, Navarro Quinones Siobana C, Santurro Letizia, Di Vittorio Francesca, Meani Francesco, Bassi Valerio, Ditsch Nina, Mueller Michael D, Bellati Filippo, Caserta Donatella, Papadia Andrea, Gentilini Oreste D

机构信息

Department of Gynecology and Obstetrics, Ospedale Regionale di Lugano EOC, via Tesserete 46, 6900 Lugano, Switzerland.

Faculty of Biomedical Sciences, Università della Svizzera Italiana (USI), via Giuseppe Buffi 13, 6900 Lugano, Switzerland.

出版信息

Cancers (Basel). 2021 Apr 24;13(9):2056. doi: 10.3390/cancers13092056.

BACKGROUND

use of fibrin sealants following pelvic, paraaortic, and inguinal lymphadenectomy may reduce lymphatic morbidity. The aim of this meta-analysis is to evaluate if this finding applies to the axillary lymphadenectomy.

METHODS

randomized trials evaluating the efficacy of fibrin sealants in reducing axillary lymphatic complications were included. Lymphocele, drainage output, surgical-site complications, and hospital stay were considered as outcomes.

RESULTS

twenty-three randomized studies, including patients undergoing axillary lymphadenectomy for breast cancer, melanoma, and Hodgkin's disease, were included. Fibrin sealants did not affect axillary lymphocele incidence nor the surgical site complications. Drainage output, days with drainage, and hospital stay were reduced when fibrin sealants were applied ( < 0.0001, < 0.005, = 0.008).

CONCLUSION

fibrin sealants after axillary dissection reduce the total axillary drainage output, the duration of drainage, and the hospital stay. No effects on the incidence of postoperative lymphocele and surgical site complications rate are found.