School of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99163, USA.
NIH Protein Biotechnology Training Program, Washington State University, Pullman, WA 99164-6240, USA.
Viruses. 2021 Apr 24;13(5):748. doi: 10.3390/v13050748.
Mosquito-borne viral infections are responsible for a significant degree of morbidity and mortality across the globe due to the severe diseases these infections cause, and they continue to increase each year. These viruses are dependent on the mosquito vector as the primary means of transmission to new vertebrate hosts including avian, livestock, and human populations. Due to the dynamic host environments that mosquito-borne viruses pass through as they are transmitted between vector and vertebrate hosts, there are various host factors that control the response to infection over the course of the pathogen's life cycle. In this review, we discuss these host factors that are present in either vector or vertebrate models during infection, how they vary or are conserved between hosts, and their implications in future research pertaining to disease prevention and treatment.
蚊媒病毒感染在全球范围内导致了相当程度的发病率和死亡率，因为这些感染会导致严重的疾病，而且每年还在不断增加。这些病毒依赖蚊子作为主要传播途径，将其传播给新的脊椎动物宿主，包括鸟类、牲畜和人类。由于蚊媒病毒在媒介和脊椎动物宿主之间传播时所经历的动态宿主环境，因此存在各种宿主因素控制着病原体生命周期过程中的感染反应。在这篇综述中，我们讨论了在感染过程中存在于媒介或脊椎动物模型中的这些宿主因素，它们在宿主之间如何变化或保守，以及它们对未来与疾病预防和治疗相关的研究的意义。
