Miyashita H
Department of Orthopaedic Surgery, Kanto Rosai Hospital, Kanagawa, Japan.
Nihon Seikeigeka Gakkai Zasshi. 1988 Mar;62(3):243-54.
To investigate the relationship between muscle atrophy and its tonus, triceps surae in four groups of rats were studied changing the muscle tonus by cutting of Achilles tendon, by shortening or lengthening of the tibia and compared with those of control groups. During the eight weeks after the operation, rats were sacrificed every week except for the seventh. The muscles were evaluated by histochemical methods (NADH-TR and myosin ATPase reaction), in which the diameter of the muscle fiber was measured according to the Brooke method. The following results were obtained; (1) Targetoid fibers were observed more frequently among type 1 fibers as the muscle tonus was decreased. (2) Diameter of both fiber types was reduced as the muscle tonus changed. (3) These changes were reversible as the muscle tonus was restored to normal.
为研究肌肉萎缩与其张力之间的关系,通过切断跟腱、缩短或延长胫骨来改变四组大鼠小腿三头肌的肌张力,并与对照组进行比较。术后八周内,除第七周外,每周处死大鼠。采用组织化学方法(NADH-TR和肌球蛋白ATP酶反应)对肌肉进行评估,按照布鲁克方法测量肌纤维直径。结果如下:(1)随着肌张力降低,在1型纤维中更频繁地观察到靶样纤维。(2)随着肌张力改变,两种纤维类型的直径均减小。(3)随着肌张力恢复正常,这些变化是可逆的。