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抗中性粒细胞胞浆抗体相关血管炎的治疗进展:近期发展与未来展望

Update in the Management of ANCA-Associated Vasculitis: Recent Developments and Future Perspectives.

作者信息

Samman Karla N, Ross Carolyn, Pagnoux Christian, Makhzoum Jean-Paul

机构信息

Vasculitis Clinic, Canadian Network for Research on Vasculitides (CanVasc), Division of Internal Medicine, Hôpital du Sacré-Coeur de Montréal, University of Montreal, Montreal, Quebec, Canada.

Vasculitis Clinic, Canadian Network for Research on Vasculitides (CanVasc), Division of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.

出版信息

Int J Rheumatol. 2021 Apr 8;2021:5534851. doi: 10.1155/2021/5534851. eCollection 2021.

Abstract

Significant progress has been made in the treatment of ANCA-associated vasculitides (AAV), notably in granulomatosis with polyangiitis and microscopic polyangiitis. Over the past few years, many innovative studies have changed the way we now induce and maintain remission in AAV; achieving remission while limiting treatment toxicity is the key. This article provides an in-depth, up-to-date summary of recent trials and suggests treatment algorithms for induction and maintenance of remission based on the latest guidelines. Future possible therapies in AAV will also be discussed.

摘要

抗中性粒细胞胞浆抗体相关性血管炎(AAV)的治疗已取得显著进展,尤其是在肉芽肿性多血管炎和显微镜下多血管炎方面。在过去几年中,许多创新性研究改变了我们目前诱导和维持AAV缓解的方式;在限制治疗毒性的同时实现缓解是关键。本文深入、最新地总结了近期试验,并根据最新指南提出了诱导和维持缓解的治疗方案。还将讨论AAV未来可能的治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/813f/8049818/9d717d96b217/IJR2021-5534851.001.jpg

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