局灶性脑损伤后的认知障碍可以更好地通过结构网络枢纽的损伤而不是功能网络枢纽的损伤来预测。
Cognitive impairment after focal brain lesions is better predicted by damage to structural than functional network hubs.
机构信息
Department of Psychiatry, Carver College of Medicine, Iowa City, IA 52242;
Department of Neurology (Division of Neuropsychology and Cognitive Neuroscience), Carver College of Medicine, Iowa City, IA, 52242.
出版信息
Proc Natl Acad Sci U S A. 2021 May 11;118(19). doi: 10.1073/pnas.2018784118.
Hubs are highly connected brain regions important for coordinating processing in brain networks. It is unclear, however, which measures of network "hubness" are most useful in identifying brain regions critical to human cognition. We tested how closely two measures of hubness-edge density and participation coefficient, derived from white and gray matter, respectively-were associated with general cognitive impairment after brain damage in two large cohorts of patients with focal brain lesions (N = 402 and 102, respectively) using cognitive tests spanning multiple cognitive domains. Lesions disrupting white matter regions with high edge density were associated with cognitive impairment, whereas lesions damaging gray matter regions with high participation coefficient had a weaker, less consistent association with cognitive outcomes. Similar results were observed with six other gray matter hubness measures. This suggests that damage to densely connected white matter regions is more cognitively impairing than similar damage to gray matter hubs, helping to explain interindividual differences in cognitive outcomes after brain damage.
枢纽是大脑中高度连接的区域，对于协调大脑网络中的处理非常重要。然而，目前尚不清楚哪种网络“枢纽度”度量标准最有助于确定对人类认知至关重要的大脑区域。我们使用涵盖多个认知领域的认知测试，在两个大型局灶性脑损伤患者队列中（分别为 402 名和 102 名患者），测试了两种枢纽度度量（分别来自白质和灰质的边缘密度和参与系数）与脑损伤后一般认知障碍的密切程度。破坏具有高边缘密度的白质区域的病变与认知障碍有关，而破坏具有高参与系数的灰质区域的病变与认知结果的相关性较弱且不那么一致。在其他六种灰质枢纽度度量上也观察到了类似的结果。这表明，与类似的灰质枢纽损伤相比，密集连接的白质区域的损伤对认知的影响更大，有助于解释脑损伤后个体认知结果的差异。
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