[环孢素A在儿童皮肌炎中的价值]

[Value of cyclosporin A in dermatomyositis in a child].

作者信息

Reinert P, Hamberger C, Rahimy M C, Dusseau C, Bernaudin F, Barre J, Tillement J P, Lemerle S

机构信息

Service de Pédiatrie, Laboratoire Hospitalo-Universitaire de Pharmacologie, Centre Hospitalier Intercommunal, Créteil.

出版信息

Arch Fr Pediatr. 1988 Mar;45(3):201-3.

PMID:3395197

Abstract

Cyclosporin A was used in a 3 1/2 year-old child with dermatomyositis exhibiting severe junctional impairment and intolerance to steroids. After a few weeks, marked clinical improvement was observed allowing a reduction of the doses of steroids. After 9 months, the clinical status was satisfactory: the calcifications had lost their inflammatory characteristics. No side effect of cyclosporin A was observed at the dose used (4.4 mg/kg/d) which maintained effective blood concentrations between 80 and 220 ng/ml.

摘要

环孢素A用于一名3岁半患有皮肌炎的儿童，该患儿表现出严重的交界区损害且对类固醇不耐受。几周后，观察到明显的临床改善，使得类固醇剂量得以减少。9个月后，临床状况令人满意：钙化灶已失去其炎症特征。在所使用的剂量（4.4毫克/千克/天）下未观察到环孢素A的副作用，该剂量使有效血药浓度维持在80至220纳克/毫升之间。