先天免疫在化疗诱导的周围神经病中的作用。
Role of innate immunity in chemotherapy-induced peripheral neuropathy.
机构信息
The Department of Pain Medicine Research, The Division of Anesthesiology, Critical Care and Pain Medicine, The University of Texas M.D. Anderson Cancer Center, United States.
The Department of Anesthesiology, Wake Forest School of Medicine, United States.
出版信息
Neurosci Lett. 2021 Jun 11;755:135941. doi: 10.1016/j.neulet.2021.135941. Epub 2021 May 4.
Abstract
It has become increasingly clear that the innate immune system plays an essential role in the generation of many types of neuropathic pain including that which accompanies cancer treatment. In this article we review current findings of the role of the innate immune system in contributing to cancer treatment pain at the distal endings of peripheral nerve, in the nerve trunk, in the dorsal root ganglion and in the spinal dorsal horn.
摘要
越来越明显的是，先天免疫系统在多种类型的神经性疼痛的产生中起着至关重要的作用，包括伴随癌症治疗的疼痛。在本文中，我们综述了先天免疫系统在导致外周神经末梢、神经干、背根神经节和脊髓背角的癌症治疗疼痛中的作用的最新发现。
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