Tournier Pierre, Guicheux Jérôme, Paré Arnaud, Veziers Joëlle, Barbeito Ana, Bardonnet Raphaël, Corre Pierre, Geoffroy Valérie, Weiss Pierre, Gaudin Alexis
INSERM, UMR 1229, RMeS, Regenerative Medicine and Skeleton, ONIRIS, Université de Nantes, Nantes, France.
BIOBank SAS, Lieusaint, France.
Front Bioeng Biotechnol. 2021 Apr 20;9:658853. doi: 10.3389/fbioe.2021.658853. eCollection 2021.
Autologous bone grafts (BGs) remain the reference grafting technique in various clinical contexts of bone grafting procedures despite their numerous peri- and post-operative limitations. The use of allogeneic bone is a viable option for overcoming these limitations, as it is reliable and it has been widely utilized in various forms for decades. However, the lack of versatility of conventional allogeneic BGs (e.g., blocks, powders) limits their potential for use with irregular or hard-to-reach bone defects. In this context, a ready- and easy-to-use partially demineralized allogeneic BG in a paste form has been developed, with the aim of facilitating such bone grafting procedures. The regenerative properties of this bone paste (BP) was assessed and compared to that of a syngeneic BG in a pre-clinical model of intramembranous bone healing in critical size defects in rat calvaria. The microcomputed tridimensional quantifications and the histological observations at 7 weeks after the implantation revealed that the bone regeneration of critical-size defects (CSDs) filled with the BP was similar to syngeneic bone grafts (BGs). Thus, this ready-to-use, injectable, and moldable partially demineralized allogeneic BP, displaying equivalent bone healing capacity than the "gold standard," may be of particular clinical relevance in the context of oral and maxillofacial bone reconstructions.
自体骨移植（BGs）在各种骨移植手术的临床环境中仍然是参考的移植技术，尽管其存在许多围手术期和术后的局限性。使用同种异体骨是克服这些局限性的可行选择，因为它可靠且已以各种形式广泛使用了数十年。然而，传统同种异体BGs（例如块状、粉末状）缺乏通用性，限制了它们用于不规则或难以触及的骨缺损的潜力。在此背景下，已开发出一种即用型且易于使用的糊状部分脱矿同种异体BG，旨在促进此类骨移植手术。在大鼠颅骨临界尺寸缺损的膜内骨愈合临床前模型中，评估了这种骨糊（BP）的再生特性，并将其与同基因BG的再生特性进行了比较。植入后7周的微型计算机三维定量分析和组织学观察表明，填充BP的临界尺寸缺损（CSDs）的骨再生与同基因骨移植（BGs）相似。因此，这种即用型、可注射且可塑形的部分脱矿同种异体BP显示出与“金标准”相当的骨愈合能力，在口腔颌面骨重建的背景下可能具有特殊的临床意义。
