Department of Pediatrics, Rush University Children's Hospital, Chicago, Illinois, USA.
Department of Pediatrics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
J Adolesc Young Adult Oncol. 2022 Feb;11(1):117-121. doi: 10.1089/jayao.2021.0041. Epub 2021 May 13.
Few studies have explored interventions to improve adolescent and young adult (AYA) cancer care delivery. While many AYAs receive cancer care at NCI Community Oncology Research Program (NCORP) sites, few enroll on clinical trials. Barriers and facilitators to pediatric oncologist activation of and enrollment on an AYA cross-network National Clinical Trials Network (NCTN) supportive care trial were assessed using a survey that was administered to 162 stakeholders representing all 47 children's oncology group (COG) institutions affiliated to an NCORP. Fifty-eight stakeholders participated representing 62% of all sites surveyed. Approximately half of participants (45%) were unaware of the trial. Seven sites had the study open and one enrolled a patient. Reasons for not opening and enrolling on the trial included limited research staff and resources, low anticipated accrual, and lower prioritization of the trial. Enrollment facilitators included having a local "AYA champion," improving communication between pediatric and medical oncology, and having site education on available AYA trials. Interventions focused on increasing site and provider awareness of AYA trials and decreasing local barriers to AYA enrollment are needed.
很少有研究探索改善青少年和年轻成人（AYA）癌症护理服务的干预措施。虽然许多 AYA 在 NCI 社区肿瘤学研究计划（NCORP）站点接受癌症护理，但很少有参加临床试验的。使用一项调查评估了儿科肿瘤学家激活和参加 AYA 跨网络国家临床试验网络（NCTN）支持性护理试验的障碍和促进因素，该调查分发给代表所有隶属于 NCORP 的 47 个儿童肿瘤学组（COG）机构的 162 名利益相关者。58 名利益相关者参加了调查，占所有调查站点的 62%。大约一半的参与者（45%）不知道这项试验。有 7 个站点开放了该研究，有 1 个站点招募了患者。未开放和招募参加试验的原因包括研究人员和资源有限、预计入组人数低以及对试验的优先级较低。招募的促进因素包括有当地的“AYA 拥护者”、改善儿科肿瘤学和肿瘤学之间的沟通，以及对可用的 AYA 试验进行站点教育。需要针对增加 AYA 试验的站点和提供者的认识，并减少 AYA 入组的地方障碍的干预措施。
