Agarwal Ashok, Farkouh Ala'a, Parekh Neel, Zini Armand, Arafa Mohamed, Kandil Hussein, Tadros Nick, Busetto Gian Maria, Ambar Rafael, Parekattil Sijo, Boitrelle Florence, Sallam Hassan, Jindal Sunil, Ko Edmund, Simopoulou Mara, Park Hyun Jun, Sadighi Mohammad Ali, Saleh Ramadan, Ramsay Jonathan, Martinez Marlon, Elbardisi Haitham, Alvarez Juan, Colpi Giovanni, Gosalvez Jaime, Evenson Donald, Shah Rupin
American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA.
Department of Urology, Cleveland Clinic, Cleveland, OH, USA.
World J Mens Health. 2022 Jan;40(1):30-37. doi: 10.5534/wjmh.210056. Epub 2021 Apr 21.
Sperm DNA fragmentation (SDF) is implicated in male infertility and adverse reproductive outcomes. With the publication of many studies regarding the etiologies and contributors to SDF, as well as the effects of SDF, guidelines are necessary to aid clinicians in the application of SDF for male fertility evaluation. Two recent clinical practice guidelines were published by Agarwal et al and Esteves et al. In this article, we have evaluated and compared both guidelines. We have found fairly similar recommendations between the two guidelines and have also highlighted the differences between them. Finally, we have summarized and combined the best practice recommendations from both guidelines.
精子DNA碎片化(SDF)与男性不育和不良生殖结局有关。随着许多关于SDF病因、影响因素以及SDF作用的研究发表,有必要制定指南以帮助临床医生在男性生育力评估中应用SDF。Agarwal等人和Esteves等人最近发表了两项临床实践指南。在本文中,我们对这两项指南进行了评估和比较。我们发现这两项指南之间的建议相当相似,同时也突出了它们之间的差异。最后,我们总结并整合了两项指南中的最佳实践建议。