Jamasbi R J, Nettesheim P, Kennel S J
Cancer Res. 1978 Feb;38(2):261-7.
Previous studies with respiratory tract tumors in mice have suggested that such tumors are not immunogenic or are only weakly so. To determine whether this is a general characteristic of neoplasias found in the airways of rodents, we investigated seven transplantable carcinomas in rats, six of which originated from tracheal epithelium and one of which orginated from the distal lung. These carcinomas were all of the squamous type and were induced by three different carcinogenic polycyclic hydrocarbons. All of the tumors were shown to be immunogenic, capable of mobilizing cellular and humoral immune responses in isogenic hosts upon immunization. This was demonstrated by induction of transplantation resistance, by Winn's neutralization test, and by the detection of antibodies in the sera of tumor-immune hosts by two independent methods (antibody-dependent cytotoxicity and antibody-binding test). The degree of immunogenicity varied among the tumor lines. The most metastatic tumor was clearly the least immunogenic. The relationship between carcinogenic insult and immunogenicity, as well as the possible nature of the tumor-associated antigens involved, is discussed.
先前对小鼠呼吸道肿瘤的研究表明，此类肿瘤不具有免疫原性或仅具有微弱的免疫原性。为了确定这是否是啮齿动物气道中肿瘤形成的普遍特征，我们研究了大鼠的七种可移植癌，其中六种起源于气管上皮，一种起源于肺远端。这些癌均为鳞状细胞类型，由三种不同的致癌多环烃诱导产生。所有肿瘤均显示具有免疫原性，在免疫后能够在同基因宿主中激发细胞免疫和体液免疫反应。这通过诱导移植抗性、温氏中和试验以及通过两种独立方法（抗体依赖性细胞毒性和抗体结合试验）检测肿瘤免疫宿主血清中的抗体得以证明。不同肿瘤系的免疫原性程度有所不同。转移性最强的肿瘤显然免疫原性最弱。本文讨论了致癌损伤与免疫原性之间的关系以及所涉及的肿瘤相关抗原的可能性质。
