The Clinical Significance and Biological Function of in Cervical Cancer.

PURPOSE

Cervical cancer is a common cancerous tumor in women that is prone to recurrence and metastasis. Recently, many people have explored the role of protocadherin 7 () in cancer and found that is abnormally expressed in many cancers. The purpose of this study is to explore the expression and mechanism of in cervical cancer and evaluate its clinical prognostic significance.

MATERIALS AND METHODS

The expression of in cervical cancer and cells was measured by qRT-PCR. The relationship between expression and the clinical prognosis was calculated using the Kaplan-Meier method and Cox regression analyses. Effects of on cancer cell proliferation, migration, and invasion were studied by MTT assay and transwell assays.

RESULTS

The expression of in cervical cancer tissues and cell lines was notably downregulated compared with the corresponding control. Low expression was associated with a low survival rate. expression was correlated with lymph node metastasis, cell differentiation, and FIGO staging. can be used as an independent prognostic factor for cervical cancer. Up-regulation of significantly inhibited the proliferation ability, migration potential, and invasion capacity of cancer cells.

CONCLUSION

may be used as a prognostic biomarker for cervical cancer patients.