Assistant Professor, Department of Pediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Junior Resident, Department of Pediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Trop Doct. 2021 Oct;51(4):591-593. doi: 10.1177/00494755211016126. Epub 2021 May 21.
Steroid-induced psychosis is a known serious adverse effect seen commonly in adults but less commonly in children. We present a seven-year-old girl with steroid-dependent nephrotic syndrome who developed abnormal behaviour, trichotillomania, alopecia and mood changes. She was investigated to rule out other causes and treated with tapering steroids, fluoxetine and olanzapine. A marked improvement was noted after two months. Patients on long term or high dose steroids should be monitored for adverse psychological effects of steroids, as early recognition and intervention can improve the outcome.
类固醇诱导的精神病是一种已知的严重不良反应,常见于成年人,但在儿童中较少见。我们报告了一例七岁女孩,患有类固醇依赖性肾病综合征,出现异常行为、拔毛癖、脱发和情绪变化。对她进行了检查以排除其他原因,并使用类固醇逐渐减量、氟西汀和奥氮平进行治疗。两个月后,病情明显改善。长期或大剂量使用类固醇的患者应监测类固醇的不良心理影响,因为早期识别和干预可以改善预后。