母亲妊娠期糖尿病与儿童期血脂异常。
Maternal gestational diabetes and childhood hyperlipidemia.
机构信息
Chronic Disease Epidemiology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.
Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China.
出版信息
Diabet Med. 2021 Nov;38(11):e14606. doi: 10.1111/dme.14606. Epub 2021 Jun 2.
AIMS
Aim of this study is to assess dyslipidemia risk between children exposed to maternal gestational diabetes mellitus (GDM) and those not exposed.
METHODS
We recruited 1144 mother-child pairs (572 GDM and 572 non-GDM women matched by their offspring's age and sex). The age of offspring ranged from 3 to 9 years old. We used general linear models to compare mean values of different lipid profiles among children born to mothers with and without GDM. Logistic regression models were used to assess associations of maternal GDM with abnormal lipid profiles in offspring.
RESULTS
After adjustment for maternal and children's characteristics, children born to mothers with GDM had lower mean values of high-density-lipoprotein (HDL) cholesterol (1.40 ± 0.01 vs. 1.50 ± 0.01; p < 0.001) and higher mean levels of triglycerides/HDL cholesterol ratio (0.37 ± 0.01 vs. 0.35 ± 0.01; p < 0.05) in comparison with their counterparts born to mothers without GDM. Multivariate-adjusted odds ratios among children exposed to mothers with GDM compared with the counterparts were 2.11 (95% confidence interval [CI 1.15-3.88]) for low HDL cholesterol and 1.35 (95% CI 1.00-1.81) for high triglycerides/HDL cholesterol ratio, respectively.
CONCLUSIONS
Maternal GDM was associated with an increased risk of hyperlipidemia in the offspring during early childhood aged from 3 to 9 years old.
目的
本研究旨在评估暴露于母体妊娠期糖尿病（GDM）和未暴露于母体 GDM 的儿童之间的血脂异常风险。
方法
我们招募了 1144 对母婴（572 例 GDM 和 572 例非 GDM 妇女按其子女的年龄和性别匹配）。子女的年龄从 3 岁到 9 岁不等。我们使用一般线性模型比较了 GDM 母亲所生孩子和未患 GDM 母亲所生孩子的不同血脂谱的平均值。使用逻辑回归模型评估了母亲 GDM 与子女血脂异常之间的关联。
结果
在调整了母亲和儿童的特征后，与未患 GDM 的母亲所生孩子相比，患有 GDM 的母亲所生孩子的高密度脂蛋白（HDL）胆固醇平均值较低（1.40±0.01 与 1.50±0.01；p<0.001），三酰甘油/高密度脂蛋白胆固醇比值平均值较高（0.37±0.01 与 0.35±0.01；p<0.05）。与未患 GDM 的母亲所生孩子相比，暴露于 GDM 母亲的儿童中，多变量调整后的比值比为 2.11（95%置信区间 [CI] 1.15-3.88）的低 HDL 胆固醇和 1.35（95% CI 1.00-1.81）的高甘油三酯/高密度脂蛋白胆固醇比值。
结论
在 3 至 9 岁的幼儿期，母体 GDM 与子女血脂异常的风险增加有关。
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