大鼠垂体前叶中II型碘甲状腺原氨酸5'-脱碘酶活性存在昼夜节律。
There is a nyctohemeral rhythm of type II iodothyronine 5'-deiodinase activity in rat anterior pituitary.
作者信息
Murakami M, Tanaka K, Greer M A
机构信息
Department of Medicine, Oregon Health Sciences University, Portland 97201.
出版信息
Endocrinology. 1988 Sep;123(3):1631-5. doi: 10.1210/endo-123-3-1631.
We found a nyctohemeral rhythm of type II iodothyronine 5'-deiodinase (5'-D-II) with a zenith at midnight in rat anterior pituitary, but not in brown adipose tissue. There was no nyctohemeral rhythm of 5'-D-I in anterior pituitary, liver, or kidney. Hypothyroidism abolished the nyctohemeral rhythmicity in anterior pituitary 5'-D-II. The rhythmicity of anterior pituitary 5'-D-II may play a role in setting the nyctohemeral rhythm of TSH secretion by regulating the degree of negative feedback by locally generated T3 in the thyrotroph.
我们发现，大鼠垂体前叶中II型碘甲状腺原氨酸5'-脱碘酶（5'-D-II）存在昼夜节律，峰值出现在午夜，但棕色脂肪组织中不存在。垂体前叶、肝脏或肾脏中5'-D-I不存在昼夜节律。甲状腺功能减退消除了垂体前叶5'-D-II的昼夜节律性。垂体前叶5'-D-II的节律性可能通过调节促甲状腺激素细胞中局部产生的T3的负反馈程度，在设定促甲状腺激素分泌的昼夜节律中发挥作用。
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