National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Chinese Center for Tropical Diseases Research, Shanghai, China.
NHC Key Laboratory of Parasite and Vector Biology, Shanghai, China.
Front Public Health. 2021 May 5;9:588325. doi: 10.3389/fpubh.2021.588325. eCollection 2021.
Clonorchiasis is a serious food-borne parasitic disease caused by infection. , a major fish-borne trematode, is a known causative agent of cholangiocarcinoma. The risk factors for infection include individual eating behaviors and environmental factors. In this study, we evaluated the infection rate and the associated risk factors among residents in Binyang County, Guangxi, China. In 2016 and 2017, five villages from Binyang, Guangxi were selected by multistage cluster random sampling for a cross-sectional study. A modified Kato-Katz thick smear method was used to examine eggs in fecal samples in triplicate (three smears for each sample). Both uni-variate and multi-variate logistic regression analyses were carried out to identify the risk factors for infection. A total of 1,977 fecal samples were collected from villagers in the investigated areas. The overall infection rates of in Binyang County was 20.49% (405/1,977). The mean age of participants was 39.42 ± 23.48 (range: 3-89 years old), and the highest infection rate (33.72%) was seen in the age group of 40-49 years old, followed by those aged 50-59 (31.83%). Multi-variate logistic regression analysis showed that higher infection rates were significantly associated with males ( = 6.51, = 4.67-9.08), Zhuang ( = 2.41, = 1.62-3.59), ages ( = 33.51, = 10.13-110.86), frequency of raw fresh fish consumption ( = 14.56, = 9.80-21.63), and close contact with cats and dogs ( = 1.53, = 1.02-2.30). Occupations and education levels showed no significant association with infection ( > 0.05). High levels of infection were observed among residents in Binyang County, Guangxi. Intervention strategies should be strengthened among the investigated population at high risk, such as males, Zhuang and older individuals, especially those who frequently eat raw fresh fish. In addition, the individuals contacting with cats and/or dogs were observed to have significantly higher infection rate of than those having no contact with cats and dogs. The association between contacting with cats and/or dogs and infection needs to be explored and confirmed in the future study by more epidemiological investigations of human infection from different areas.
肝吸虫病是一种由 感染引起的严重食源性寄生虫病。肝吸虫，一种主要的鱼类吸虫，是胆管癌的已知病原体。 感染的危险因素包括个人饮食习惯和环境因素。本研究评估了中国广西宾阳县居民的 感染率及相关危险因素。2016 年至 2017 年，采用多阶段整群随机抽样方法，从广西宾阳的 5 个村庄中抽取了一个横断面研究。采用改良加藤厚涂片法对粪便样本中的 卵进行了三次重复检查（每个样本三张涂片）。采用单变量和多变量逻辑回归分析来确定 感染的危险因素。共采集了调查地区村民的 1977 份粪便样本。宾阳县的总体 感染率为 20.49%（405/1977）。参与者的平均年龄为 39.42±23.48 岁（范围：3-89 岁），年龄在 40-49 岁的人群感染率最高（33.72%），其次是 50-59 岁的人群（31.83%）。多变量逻辑回归分析显示，男性（比值比[OR]=6.51，95%置信区间[CI]：4.67-9.08）、壮族（OR=2.41，95%CI：1.62-3.59）、年龄（OR=33.51，95%CI：10.13-110.86）、食用生淡水鱼的频率（OR=14.56，95%CI：9.80-21.63）和与猫、狗的密切接触（OR=1.53，95%CI：1.02-2.30）与较高的感染率显著相关。职业和教育水平与 感染无显著相关性（>0.05）。宾阳县居民的 感染水平较高。应在高危人群中加强干预策略，如男性、壮族和老年人，特别是那些经常食用生淡水鱼的人群。此外，与猫和/或狗接触的个体的 感染率明显高于没有与猫和/或狗接触的个体。未来需要通过不同地区人群 感染的更多流行病学调查来探讨和证实与猫和/或狗接触与 感染之间的关系。
