TU Wien, Institute for Information Systems Engineering, Vienna, Austria.
dwh simulation services, dwh GmbH, Vienna, Austria.
Med Decis Making. 2021 Nov;41(8):1017-1032. doi: 10.1177/0272989X211013306. Epub 2021 May 22.
Many countries have already gone through several infection waves and mostly managed to successfully stop the exponential spread of SARS-CoV-2 through bundles of restrictive measures. Still, the danger of further waves of infections is omnipresent, and it is apparent that every containment policy must be carefully evaluated and possibly replaced by a different, less restrictive policy before it can be lifted. Tracing of contacts and consequential breaking of infection chains is a promising strategy to help contain the disease, although its precise impact on the epidemic is unknown.
In this work, we aim to quantify the impact of tracing on the containment of the disease and investigate the dynamic effects involved.
We developed an agent-based model that validly depicts the spread of the disease and allows for exploratory analysis of containment policies. We applied this model to quantify the impact of different approaches of contact tracing in Austria to derive general conclusions on contract tracing.
The study displays that strict tracing complements other intervention strategies. For the containment of the disease, the number of secondary infections must be reduced by about 75%. Implementing the proposed tracing strategy supplements measures worth about 5%. Evaluation of the number of preventively quarantined persons shows that household quarantine is the most effective in terms of avoided cases per quarantined person.
The results are limited by the validity of the modeling assumptions, model parameter estimates, and the quality of the parametrization data.
The study shows that tracing is indeed an efficient measure to keep case numbers low but comes at a high price if the disease is not well contained. Therefore, contact tracing must be executed strictly, and adherence within the population must be held up to prevent uncontrolled outbreaks of the disease.
许多国家已经经历了几波感染,通过一系列限制措施,大多成功地阻止了 SARS-CoV-2 的指数级传播。然而,进一步感染浪潮的危险仍然存在,显然,在取消之前,必须仔细评估每一项遏制政策,并在必要时用不同的、限制较小的政策取代它。追踪接触者并由此打破感染链是一种有前途的控制疾病的策略,尽管其对疫情的确切影响尚不清楚。
在这项工作中,我们旨在量化追踪对疾病控制的影响,并研究所涉及的动态效应。
我们开发了一个基于代理的模型,该模型有效地描述了疾病的传播,并允许对遏制政策进行探索性分析。我们应用这个模型来量化不同的接触追踪方法在奥地利的影响,以得出关于接触追踪的一般结论。
研究表明,严格的追踪补充了其他干预策略。为了控制疾病,必须减少约 75%的二次感染。实施建议的追踪策略可以补充约 5%的措施。评估预防性隔离人数表明,在避免每隔离一人的病例方面,家庭隔离是最有效的。
结果受到建模假设、模型参数估计和参数化数据质量的有效性的限制。
该研究表明,追踪确实是一种有效的控制病例数量的措施,但如果疾病不能得到很好的控制,其代价也很高。因此,接触追踪必须严格执行,必须保持公众的遵守,以防止疾病的失控爆发。