From the Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University; and Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province; and Academician (Expert) Workstation of Sichuan Province, Luzhou, Sichuan, China.
Clin Nucl Med. 2021 Dec 1;46(12):1018-1019. doi: 10.1097/RLU.0000000000003716.
A 48-year-old man presented with a painless enlarging mass on his right thigh for 2 months. He had a history of neurofibromatosis. MRI showed a mass in his right thigh. Malignant tumor was suspected. He was enrolled in the clinical trial of 68Ga-FAPI in solid tumors. Multiple increased FAPI uptake was observed in the right thigh mass, lung, and mediastinal lymph nodes, which were confirmed being pleomorphic rhabdomyosarcoma by biopsy. In addition, widespread metabolic activity was also observed in his cutaneous fibroma nodules. This case showed that benign neurofibromatosis can cause FAPI uptake.
一位 48 岁男性，2 个月来右大腿无痛性增大肿块。他有神经纤维瘤病病史。MRI 显示右大腿有一肿块，疑为恶性肿瘤。他参加了实体瘤 68Ga-FAPI 的临床试验。右大腿肿块、肺部和纵隔淋巴结多处 FAPI 摄取增加，经活检证实为多形性横纹肌肉瘤。此外，他的皮肤纤维瘤结节也有广泛的代谢活性。本病例表明良性神经纤维瘤也可引起 FAPI 摄取。
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