Legal Medicine and Toxicology, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Italy Padova.
Traffic Inj Prev. 2021;22(5):355-360. doi: 10.1080/15389588.2021.1923701. Epub 2021 May 26.
This study investigates the consequences of the SarS-CoV-2 outbreak and of the resulting control measures on alcohol and illicit substance use in a high-risk population for substance-related disorders, utilizing an integrated medico-legal and toxicological approach.
The research was structured as a retrospective case-control study of subjects found to be driving under the influence (DUI) of alcohol and/or other psychoactive substances who were examined for driver's license regranting. Alcohol and/or drug use was assessed by comparing cases examined in the period from May to August 2020 (immediately after the lockdown in Italy) to control subjects examined in the same period in 2019. DUI subjects were examined by an integrated approach, descriptive analyses were conducted, and significance was determined by chi-square and Mann-Whitney tests. Variables linked to the pandemic outbreak and resulting lockdown were investigated as predictive factors in determining unfitness to drive.
Cases (281) were significantly different from controls (261) concerning the judgment of unfitness to drive (p<.001) and had more subjects with chronic excessive alcohol use and/or illicit substance use. The two groups were rather homogeneous concerning the other variables, except for a difference in blood alcohol concentration (BAC) at the time of DUI (p = .027). No statistical association was found between the investigated variables linked to the lockdown and the judgment of unfitness to drive.
Chronic excessive alcohol consumption and illicit substance use were more frequently observed in cases, which suggests a possible correlation between the pandemic/lockdown restrictions and an increase in psychoactive substance misuse. While these potentially correlative factors are discussed in this article, they require further study. If confirmed, the results should be considered in forensic and clinical settings.
本研究通过综合法医学和毒理学方法,调查 SARS-CoV-2 爆发及其导致的控制措施对物质相关障碍高危人群中酒精和非法物质使用的影响。
该研究采用回顾性病例对照研究设计,对因酒后或其他精神活性物质驾车而接受驾驶执照重新发放检查的患者进行研究。通过比较 2020 年 5 月至 8 月(意大利封锁后立即)与 2019 年同期接受检查的病例和对照,评估酒精和/或药物使用情况。对酒后驾车者进行综合评估,进行描述性分析,并通过卡方检验和曼-惠特尼检验确定显著性。将与大流行爆发和随之而来的封锁相关的变量作为确定驾驶不适的预测因素进行调查。
病例组(281 例)与对照组(261 例)在驾驶不适的判断方面存在显著差异(p<.001),且有更多的慢性过度饮酒和/或非法物质使用者。两组在其他变量方面相当一致,除了 DUI 时的血液酒精浓度(BAC)差异(p =.027)。未发现与封锁相关的调查变量与驾驶不适的判断之间存在统计学关联。
病例组中慢性过度饮酒和非法物质使用更为常见,这表明大流行/封锁限制可能与精神活性物质滥用增加之间存在关联。虽然本文讨论了这些潜在的相关因素,但它们需要进一步研究。如果得到证实,结果应在法医和临床环境中得到考虑。