Saunders Philippa T K, Horne Andrew W
EXPPECT Centre, The University of Edinburgh, Edinburgh Bioquarter, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.
EXPPECT Centre, The University of Edinburgh, Edinburgh Bioquarter, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.
Cell. 2021 May 27;184(11):2807-2824. doi: 10.1016/j.cell.2021.04.041.
Endometriosis is a common condition associated with infertility that causes chronic pain in many, but not all, women. It is defined by the presence of endometrial-like tissue outside the uterus. Although the cause and natural history of the disorder remain uncertain, hormonal, neurological, and immunological factors are all implicated in the mechanisms contributing to development of symptoms. Because definitive diagnosis requires surgery, there is often a long diagnostic delay after onset of symptoms. Current interventions for endometriosis have limited efficacy and unacceptable side effects/risks and are associated with high rates of symptom recurrence. Here, we review recent advances in our understanding of the etiology of endometriosis, discuss current diagnostic and treatment strategies, highlight current clinical trials, and consider how recent results offer new avenues for the identification of endometriosis biomarkers and the development of effective non-surgical therapies that are fertility-sparing.
子宫内膜异位症是一种与不孕症相关的常见病症，会导致许多（但并非所有）女性出现慢性疼痛。它的定义是子宫外存在类似子宫内膜的组织。尽管该病症的病因和自然病史仍不明确，但激素、神经和免疫因素都与症状发展的机制有关。由于明确诊断需要手术，症状出现后往往会有很长的诊断延迟。目前针对子宫内膜异位症的干预措施疗效有限且副作用/风险不可接受，并且症状复发率很高。在此，我们回顾了我们对子宫内膜异位症病因理解的最新进展，讨论了当前的诊断和治疗策略，突出了当前的临床试验，并考虑近期的研究结果如何为子宫内膜异位症生物标志物的识别以及有效且保留生育能力的非手术疗法的开发提供新途径。
