Department of Neurology, The Second Medical Center, People's Liberation Army General Hospital, Beijing, 100853, China.
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
Neurosci Bull. 2021 Jul;37(7):1025-1038. doi: 10.1007/s12264-021-00701-z. Epub 2021 May 29.
Alzheimer's disease (AD) is the most common cognitive disorder in the elderly. Its main clinical manifestations are cognitive decline (C), behavioral and psychological symptoms (B), and a decline in the activities of daily living (A), also known as ABC symptoms. Early identification and evaluation of ABC symptoms are helpful for establishing the accurate diagnosis, comprehensive treatment, and prognosis of AD. To guide Chinese clinical practice for optimization of the comprehensive management of AD, in 2018, The Academy of Cognitive Disorder of China gathered 22 neurologists and gerontologists in China to build a consensus on the comprehensive management of AD. Based on a review of the evidence, the consensus summarizes the pathogenesis, pathological changes, clinical manifestations, evaluation, diagnosis, drug and non-drug treatment, and patient care for AD. Focus group discussion was used to establish a flowchart of comprehensive ABC management for AD patients. The new consensus provides a feasible AD management process for clinicians.
阿尔茨海默病（AD）是老年人最常见的认知障碍。其主要临床表现为认知下降（C）、行为和心理症状（B）以及日常生活活动能力下降（A），也称为 ABC 症状。早期识别和评估 ABC 症状有助于准确诊断、全面治疗和预后 AD。为了指导中国临床实践，优化 AD 的综合管理，中国认知障碍学会于 2018 年召集了 22 名神经病学和老年病学专家，就 AD 的综合管理达成共识。该共识基于对证据的回顾，总结了 AD 的发病机制、病理变化、临床表现、评估、诊断、药物和非药物治疗以及患者护理。使用焦点小组讨论为 AD 患者制定了综合 ABC 管理流程图。新的共识为临床医生提供了可行的 AD 管理流程。
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