Shaiba Lana A, Hadid Adnan, Altirkawi Khalid A, Bakheet Hind M, Alherz Aminah Mohammed, Hussain Shaik Asfaq, Sobaih Badr H, Alnemri Abdulrahman M, Almaghrabi Rana, Ahmed Medina, Arafah Maria A, Jarallah Abdullah, Bukhari Elham Essa, Alzamil Fahad A
Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Neonatology, King Saud University Medical City, Riyadh, Saudi Arabia.
Front Pediatr. 2021 May 13;9:652857. doi: 10.3389/fped.2021.652857. eCollection 2021.
Vertical transmission of SARS-CoV-2 is under investigation. A few reports suggest the possibility of SARS-CoV-2 transmission from mothers to their neonates. Most neonates have mild symptoms, but some develop multisystem involvement and shock. We report two cases of possible SARS-CoV-2 vertical transmission from mothers to their neonates. The first case shows maternal infection with SARS-CoV-2 in the second trimester followed by recurrent infection in the third trimester right before the delivery. The infant demonstrated respiratory distress soon after delivery along with myocardial dysfunction and multi-organ system involvement. The second case shows maternal infection with SARS-COV-2 at the time of delivery with preterm labor secondary to placental abruption, with that delivery resulting in the preterm neonate requiring non-invasive ventilation with multisystem involvement in the context of persistently positive SARS-COV-2 PCR in the neonate. Both neonates were treated with IVIG along with steroids. Both neonates recovered fully and were discharged and allowed to go home. In neonates, COVID-19 usually presents as an asymptomatic or mild illness; some may develop a more severe course. Our two cases, however, demonstrate that multisystem involvement, although rare, is possible. This report also supports the current evidence of possible vertical transmission from mothers to their neonates. This multisystem involvement might be underreported and should be considered in neonates with respiratory distress when born to mothers suffering of COVID-19. [KSUMC], identifier [No#98763298].
新型冠状病毒2（SARS-CoV-2）的垂直传播正在研究中。一些报告表明存在SARS-CoV-2从母亲传播给新生儿的可能性。大多数新生儿症状轻微，但有些会出现多系统受累和休克。我们报告了两例可能的SARS-CoV-2从母亲垂直传播给新生儿的病例。第一例显示母亲在孕中期感染SARS-CoV-2，随后在分娩前的孕晚期再次感染。婴儿出生后不久即出现呼吸窘迫，伴有心肌功能障碍和多器官系统受累。第二例显示母亲在分娩时感染SARS-CoV-2，因胎盘早剥导致早产，该分娩导致早产新生儿需要无创通气，且新生儿SARS-CoV-2聚合酶链反应（PCR）持续呈阳性，伴有多系统受累。两名新生儿均接受了静脉注射免疫球蛋白（IVIG）和类固醇治疗。两名新生儿均完全康复并出院回家。在新生儿中，冠状病毒病（COVID-19）通常表现为无症状或轻症疾病；有些可能会发展为更严重的病程。然而，我们的两例病例表明，多系统受累虽然罕见，但也是可能的。本报告也支持目前关于可能从母亲垂直传播给新生儿的证据。这种多系统受累情况可能报告不足，对于COVID-19感染母亲所生的有呼吸窘迫的新生儿应予以考虑。[堪萨斯大学医学中心（KSUMC）]，标识符[编号98763298]
