重金属与成体神经发生
Heavy metals and adult neurogenesis.
作者信息
Wang Hao, Matsushita Megumi T
机构信息
Toxicology Program, Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.
出版信息
Curr Opin Toxicol. 2021 Jun;26:14-21. doi: 10.1016/j.cotox.2021.03.006. Epub 2021 Apr 7.
Abstract
With extensive use in industrial and agriculture applications, overexposure to heavy metals has become a global public health concern. The nervous system is vulnerable to many heavy metals, including cadmium, lead, and mercury. However, the knowledge about the underlying mechanisms of these metals' neurotoxicity is still very limited. Adult neurogenesis is a process of generating functional neurons from adult neural progenitor/stem cells (aNPCs), which plays an important role in cognitive function and olfaction. The studies of adult neurogenesis provide new insights into mechanisms of heavy metal neurotoxicity. This review summarizes the current research about the effects of heavy metals on adult neurogenesis and discusses their importance in understanding the mechanisms of heavy metals neurotoxicity, as well as challenges and future directions.
摘要
随着重金属在工农业中的广泛应用，过度接触重金属已成为全球公共卫生关注的问题。神经系统易受多种重金属影响，包括镉、铅和汞。然而，关于这些金属神经毒性潜在机制的了解仍然非常有限。成体神经发生是指从成年神经祖细胞/干细胞（aNPCs）产生功能性神经元的过程，其在认知功能和嗅觉中发挥重要作用。成体神经发生的研究为重金属神经毒性机制提供了新的见解。本综述总结了目前关于重金属对成体神经发生影响的研究，并讨论了它们在理解重金属神经毒性机制中的重要性，以及面临的挑战和未来方向。
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本文引用的文献
1
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ACS Biomater Sci Eng. 2018 May 14;4(5):1908-1915. doi: 10.1021/acsbiomaterials.8b00160. Epub 2018 Mar 29.
2
Single-cell RNA sequencing of mouse neural stem cell differentiation reveals adverse effects of cadmium on neurogenesis.单细胞 RNA 测序揭示了镉对神经发生的不利影响
Food Chem Toxicol. 2021 Feb;148:111936. doi: 10.1016/j.fct.2020.111936. Epub 2020 Dec 31.
3
Association of arsenic exposure and cognitive impairment: A population-based cross-sectional study in China.砷暴露与认知障碍的关联：基于人群的横断面研究在中国。
Neurotoxicology. 2021 Jan;82:100-107. doi: 10.1016/j.neuro.2020.11.009. Epub 2020 Nov 26.
4
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Front Cell Dev Biol. 2020 Sep 16;8:860. doi: 10.3389/fcell.2020.00860. eCollection 2020.
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Neurotoxicology. 2020 Dec;81:127-136. doi: 10.1016/j.neuro.2020.09.038. Epub 2020 Oct 8.
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7
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8
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9
Manganese induced nervous injury by α-synuclein accumulation via ATP-sensitive K(+) channels and GABA receptors.锰通过ATP敏感性钾通道和GABA受体导致α-突触核蛋白积累，进而引起神经损伤。
Toxicol Lett. 2020 Oct 10;332:164-170. doi: 10.1016/j.toxlet.2020.07.008. Epub 2020 Jul 10.
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