SYNTAX 评分对合并 2 型糖尿病的稳定型冠状动脉疾病患者糖尿病视网膜病变的预测价值。

Predictive value of the SYNTAX score for diabetic retinopathy in stable coronary artery disease patients with a concomitant type 2 diabetes mellitus.

机构信息

Hatay Mustafa Kemal University, Tayfur Ata Sökmen Faculty of Medicine, Department of Ophthalmology, Hatay, Turkey.

Hatay Mustafa Kemal University, Tayfur Ata Sökmen Faculty of Medicine, Department of Cardiology, Hatay, Turkey.

出版信息

Diabetes Res Clin Pract. 2021 Jul;177:108875. doi: 10.1016/j.diabres.2021.108875. Epub 2021 May 29.

DOI:10.1016/j.diabres.2021.108875

PMID:34058301

Abstract

AIMS

Diabetic retinopathy (DR) is a serious complication of type 2 diabetes mellitus (T2DM) and is the most common cause of impaired vision for adults. DR is related to a number of risk factors. The aim of this study was to investigate the relationship between burden of coronary artery disease assessed by Syntax Score (SS) and DR in T2DM.

METHODS

A total of 96 T2DM patients undergoing coronary angiography were prospectively included in the study. Presence and severity of DR were assessed by ocular fundus examination. DR was graded as no apparent retinopathy (NDR), non-proliferative (NPDR), and proliferative DR (PDR). The SS for each patient was calculated.

RESULTS

The mean age was 58.0 ± 8.2 years. SS gradually increased from NDR group to PDR group. The median (IQR) value of SS was 10 (5-16) in patients with NDR, 22.8 (17-35.8) in those with NPDR, and 35.5 (28-37) in those with PDR (p < 0.001). On multivariate analysis SS [odds ratio (OR) 1.145, p = 0.001] and duration of diabetes (OR 1.753, p = 0.031) were independent factors for DR.

CONCLUSIONS

The SS is independently associated with the occurrence of DR in T2DM. Ophthalmologists and cardiologists must cooperate when evaluating patients with DM because of possible complications.

摘要

目的

糖尿病视网膜病变（DR）是 2 型糖尿病（T2DM）的严重并发症，也是成年人视力障碍的最常见原因。DR 与许多危险因素有关。本研究旨在探讨Syntax 评分（SS）评估的冠状动脉疾病负担与 T2DM 中 DR 的关系。

方法

前瞻性纳入 96 例接受冠状动脉造影的 T2DM 患者。通过眼部眼底检查评估 DR 的存在和严重程度。DR 分为无明显视网膜病变（NDR）、非增生性（NPDR）和增生性 DR（PDR）。计算每位患者的 SS。

结果

患者平均年龄为 58.0±8.2 岁。SS 从 NDR 组逐渐升高至 PDR 组。NDR 患者的 SS 中位数（IQR）值为 10（5-16），NPDR 患者为 22.8（17-35.8），PDR 患者为 35.5（28-37）（p<0.001）。多变量分析显示 SS[比值比（OR）1.145，p=0.001]和糖尿病病程（OR 1.753，p=0.031）是 DR 的独立因素。