细胞质 LXR 表达是早期原发性乳腺癌患者预后不良的独立标志物。
Cytoplasmic LXR expression is an independent marker of poor prognosis for patients with early stage primary breast cancer.
机构信息
Department of Obstetrics and Gynecology, Breast Center, LMU University Hospital, Munich, Germany.
Department of Breast Center, School of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, 310003, China.
出版信息
J Cancer Res Clin Oncol. 2021 Sep;147(9):2535-2544. doi: 10.1007/s00432-021-03670-y. Epub 2021 Jun 3.
PURPOSE
The aim of this study was to investigate the expression of liver X receptors α/β (LXR) in primary breast cancer (BC) tissues and to analyze its correlations with clinicopathological parameters including patient survival.
METHODS
In a well-characterized cohort of 305 primary BC, subcellular distribution of LXR was evaluated by immunohistochemistry. Correlations with clinicopathological characteristics as well as with patient outcome were analyzed.
RESULTS
LXR was frequently localized in both nuclei and cytoplasms of BC cells, with stronger staining in nuclei. Total and nuclear LXR expression was positively correlated with ER and PR status. Overall survival analysis demonstrated that cytoplasmic LXR was significantly correlated with poor survival and appeared as an independent marker of poor prognosis, in stage I but not in stage II-III tumors CONCLUSION: Altogether, these data suggest that cytoplasmic LXR could be defined as a prognostic marker in early stage primary BC.
目的
本研究旨在探讨肝 X 受体 α/β（LXR）在原发性乳腺癌（BC）组织中的表达，并分析其与包括患者生存在内的临床病理参数的相关性。
方法
在一个经过良好特征描述的 305 例原发性 BC 队列中，通过免疫组织化学评估 LXR 的亚细胞分布。分析与临床病理特征以及与患者预后的相关性。
结果
LXR 经常定位于 BC 细胞的细胞核和细胞质中，细胞核中的染色较强。总 LXR 和核 LXR 的表达与 ER 和 PR 状态呈正相关。总体生存分析表明，细胞质 LXR 与不良预后显著相关，并且在 I 期肿瘤而不是 II-III 期肿瘤中，作为独立的预后不良标志物。
结论
总之，这些数据表明，细胞质 LXR 可作为早期原发性 BC 的预后标志物。
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