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鞘内药物递送治疗干燥综合征诱导的横贯性脊髓炎后难治性神经病理性疼痛:一例报告。

Intrathecal drug delivery to treat intractable neuropathic pain following Sjögren's syndrome-induced transverse myelitis: A case report.

机构信息

Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul.

Department of Anesthesiology and Pain Medicine, Keimyung University Dongsan Hospital, Daegu.

出版信息

Medicine (Baltimore). 2021 Jun 4;100(22):e26141. doi: 10.1097/MD.0000000000026141.

Abstract

RATIONALE

Transverse myelitis (TM) is a spinal cord inflammatory myelopathy that causes motor/sensory loss and urinary retention below the level of the affected spinal cord. Although a few case reports have described the control of neuropathic pain in patients with TM via spinal cord stimulation, no documented case regarding the control of severe allodynia following TM via intrathecal pump has been described.

PATIENT CONCERNS

A 37-year-old woman was referred to a pain clinic for severe intractable pain below the T5 level followed by Sjögren's syndrome-induced TM.

DIAGNOSES

A neurological examination revealed paresthesia and allodynia below the T5 level. The sensory evaluation was limited by extreme pain and jerking movements. The muscle strength of both lower limbs was grade 3.

INTERVENTIONS

Intrathecal pump was inserted into the left lower abdomen. Catheter tip was placed at the midline of the T8 level.

OUTCOMES

The numeric rating scale (NRS) for pain score decreased from 10 to 5. Functional Independence Measure score increased from 67 before implantation to 92 at the time of discharge, while the patient's Barthel score increased from 31 to 46.

LESSONS

Neuropathic pain due to Sjögren's syndrome-related TM could be controlled effectively using the intrathecal morphine pump.

摘要

背景

横贯性脊髓炎(TM)是一种脊髓炎性脱髓鞘疾病,可导致受累脊髓以下的运动/感觉丧失和尿潴留。虽然有少数病例报告描述了通过脊髓刺激来控制 TM 患者的神经性疼痛,但尚未有记录在案的通过鞘内泵来控制 TM 后严重感觉过敏的病例。

患者关注

一位 37 岁女性因严重的难治性疼痛(T5 以下)并伴有干燥综合征引起的 TM 而被转诊至疼痛诊所。

诊断

神经系统检查显示 T5 以下感觉异常和感觉过敏。感觉评估受到极度疼痛和抽搐运动的限制。双下肢肌力均为 3 级。

干预措施

在左下腹插入鞘内泵。导管尖端位于 T8 水平的中线。

结果

疼痛评分的数字评定量表(NRS)从 10 分降至 5 分。功能独立性测量评分从植入前的 67 分增加到出院时的 92 分,而患者的巴氏量表从 31 分增加到 46 分。

经验教训

干燥综合征相关 TM 引起的神经性疼痛可以通过鞘内吗啡泵有效控制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7a2/8183848/18294207de79/medi-100-e26141-g001.jpg

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