Seike Yuki, Kawagishi Yukio, Bando Akihito, Kimoto Ko, Hongo Masato, Takeda Shinichi
Department of Respiratory Medicine Kurobe City Hospital Kurobe Japan.
Department of Internal Medicine Kurobe City Hospital Kurobe Japan.
Respirol Case Rep. 2021 May 25;9(6):e00767. doi: 10.1002/rcr2.767. eCollection 2021 Jun.
Two male smokers developed small-cell lung cancer (SCLC) as the second primary malignancy (SPM) in the irradiated field after concurrent chemoradiotherapy for locally advanced cancer, which could also be considered as a radiation-induced tumour. A 70-year-old man received cisplatin and S-1 and irradiation at 60 Gy for lung adenocarcinoma eight years previously and an 81-year-old man cisplatin and 5-fluorouracil and at irradiation 60 Gy for oesophageal cancer five years previously. They sequentially received chemotherapy for SCLC, the effects of which were limited, and a refractory course was noted. Chemoradiotherapy is an effective treatment strategy for locally advanced cancer but may be relevant to the onset of SCLC as SPM.
两名男性吸烟者在接受局部晚期癌症同步放化疗后，在照射野内发生了小细胞肺癌（SCLC），作为第二原发性恶性肿瘤（SPM），这也可被视为辐射诱导的肿瘤。一名70岁男性八年前因肺腺癌接受了顺铂和S-1治疗以及60 Gy的照射，另一名81岁男性五年前因食管癌接受了顺铂和5-氟尿嘧啶治疗以及60 Gy的照射。他们随后接受了SCLC的化疗，但其效果有限，病程呈难治性。同步放化疗是局部晚期癌症的有效治疗策略，但可能与SCLC作为SPM的发生有关。
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