甘油三酯/高密度脂蛋白胆固醇（TG/HDL-C）比值升高的儿童和青少年中胆固醇酯转运蛋白及脂蛋白相关磷脂酶A2活性增加

Increased Cholesteryl Ester Transfer Protein and Lipoprotein-Associated Phospholipase A2 Activities in Children and Adolescents Presenting High Triglyceride/High-Density Lipoprotein Cholesterol (TG/HDL-C) Ratio.

作者信息

Ferraro Florencia, Martín Maximiliano, Verona Julian, Gilligan Lisandro, Verona Maria Florencia, Botta Eliana, Tetzlaff Walter, Lozano Chiappe Ezequiel, Boero Laura, Brites Fernando

机构信息

Laboratorio de Lípidos y Aterosclerosis, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Av. Córdoba 2351, C1120, Buenos Aires, Argentina.

Hospital Municipal de Balcarce "Dr. Felipe A. Fossatti", Calle 19 926, Balcarce, Buenos Aires, Argentina.

出版信息

Indian J Pediatr. 2021 Dec;88(12):1180-1186. doi: 10.1007/s12098-021-03806-5. Epub 2021 Jun 7.

DOI:10.1007/s12098-021-03806-5

PMID:34097230

Abstract

OBJECTIVE

To explore the association between Triglyceride/High-density lipoprotein cholesterol (TG/HDL-C) index and these enzymes and proteins in a pediatric population.

METHODS

Children and adolescents (7-14 y old) were recruited (n = 150) and anthropometric data were registered. Glucose, TG, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), HDL-C plus cholesteryl ester transfer protein (CETP), lipoprotein-associated phospholipase A (Lp-PLA) and paraoxonase 1 (PON1) activities were determined.

RESULTS

Twenty-five individuals presented TG/HDL-C ratio ≥ 3.0. These individuals exhibited higher TG [164 (126-186) vs. 65 (48-72) mg/dL; p < 0.01] CETP [250 (232-263) vs. 223 (193-237)% mL/min; p < 0.01] and Lp-PLA (4.5 ± 1.9 vs. 3.5 ± 1.3; p < 0.05) plus lower HDL-C [41 (37-49) vs. 52 (48-62) mg/dL; p < 0.01] compared to an age-matched group with TG/HDL-C < 3.0. TG/HDL-C ratio was associated to CETP (p < 0.01) and Lp-PLA (p < 0.05). Multiple lineal regression analyses showed TG/HDL-C index as an independent predictor of CETP (r = 0.29; beta = 0.49; p < 0.01) and Lp-PLA (r = 0.21; beta = 0.32; p < 0.05) activities.

CONCLUSION

Children and adolescents with TG/HDL-C ≥ 3.0 presented a more atherogenic lipid profile and higher CETP and Lp-PLA activities, which would indicate alterations in lipoprotein metabolism and quality.

摘要

目的

探讨儿童群体中甘油三酯/高密度脂蛋白胆固醇（TG/HDL-C）指数与这些酶及蛋白质之间的关联。

方法

招募7至14岁的儿童和青少年（n = 150），记录人体测量数据。测定血糖、甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）以及胆固醇酯转运蛋白（CETP）、脂蛋白相关磷脂酶A（Lp-PLA）和对氧磷酶1（PON1）的活性。

结果

25名个体的TG/HDL-C比值≥3.0。与年龄匹配的TG/HDL-C < 3.0组相比，这些个体的TG水平更高[164（126 - 186）对65（48 - 72）mg/dL；p < 0.01]，CETP水平更高[250（232 - 263）对223（193 - 237）% mL/min；p < 0.01]，Lp-PLA水平更高（4.5 ± 1.9对3.5 ± 1.3；p < 0.05），而HDL-C水平更低[41（37 - 49）对52（48 - 62）mg/dL；p < 0.01]。TG/HDL-C比值与CETP（p < 0.01）和Lp-PLA（p < 0.05）相关。多元线性回归分析显示，TG/HDL-C指数是CETP（r = 0.29；β = 0.49；p < 0.01）和Lp-PLA（r = 0.21；β = 0.32；p < 0.05）活性的独立预测指标。