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药物:是福还是祸:与药物相关的就诊引发的紧急情况。

Medication - A boon or bane: Emergencies due to medication-related visits.

机构信息

Department of Emergency Medicine, Christian Medical College, Vellore, Tamil Nadu, India.

出版信息

Indian J Pharmacol. 2021 Mar-Apr;53(2):103-107. doi: 10.4103/ijp.IJP_357_20.

Abstract

BACKGROUND

Medication-related visits (MRV) to the Emergency Department (ED) are substantial though weakly recognized and intervened. Data from developing countries on the prevalence of MRV-related ED admissions are scanty. This study is first of its kind in India to estimate the prevalence of MRV, its severity and the factors contributing to these visits.

METHODOLOGY

This prospective observational study was done in the ED of an apex tertiary care center in August 2018. A convenient cross-sectional sample of patients presenting with emergencies regarding drug use or ill-use were included and a questionnaire filled after obtaining a written informed consent.

RESULTS

During the study period, a cross-sectional sample of 443 patients was studied and the prevalence of MRV was 27.1% (120/443). The mean age was 55 (standard deviation: 15) years with a male preponderance (60.8%). Triage priority I patients comprised 39.1%. Common presenting complaints included vomiting (25%), seizure (20.8%), giddiness (20%), and abdomen pain (17.5%). Less than ½ (43.3%) were compliant to prescribed medication. The most common reasons for MRV were failure to receive drugs/noncompliance (47.5%), subtherapeutic dosage (25%), and adverse drug reaction (16.7%). Severity of MRV was classified as mild (50%), moderate (38.3%), and severe (11.7%). Out of these visits, 71 (59.2%) were deemed preventable. Three-fourths (73.3%) were stabilized and discharged from the ED.

CONCLUSION

The fact that a quarter of the ED visits are due to MRV and that more than half of them are preventable is quite alarming. Diligent patient education by the treating physicians may perhaps help in decreasing the incidence of this deleterious event.

摘要

背景

尽管药物相关就诊(MRV)到急诊部(ED)的情况很普遍,但却没有得到充分的认识和干预。关于发展中国家 MRV 相关 ED 入院率的数据很少。这项研究是印度首例此类研究,旨在估计 MRV 的流行率、其严重程度以及导致这些就诊的因素。

方法

这项前瞻性观察研究于 2018 年 8 月在一家顶级三级保健中心的 ED 进行。纳入了因药物使用或滥用而出现急症的便利横断面样本患者,并在获得书面知情同意后填写了问卷。

结果

在研究期间,对 443 名患者进行了横断面样本研究,MRV 的患病率为 27.1%(120/443)。平均年龄为 55(标准差:15)岁,男性居多(60.8%)。分诊优先级 I 的患者占 39.1%。常见的首发症状包括呕吐(25%)、癫痫发作(20.8%)、头晕(20%)和腹痛(17.5%)。不到一半(43.3%)的患者遵医嘱服药。MRV 的最常见原因是未收到药物/不遵医嘱(47.5%)、治疗剂量不足(25%)和药物不良反应(16.7%)。MRV 的严重程度分为轻度(50%)、中度(38.3%)和重度(11.7%)。在这些就诊中,71 例(59.2%)被认为是可预防的。四分之三(73.3%)患者经 ED 稳定并出院。

结论

事实上,四分之一的 ED 就诊是由于 MRV,而且超过一半的就诊是可以预防的,这令人相当震惊。治疗医生对患者进行认真的教育可能有助于减少这种有害事件的发生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bab3/8265416/ab77e8dec498/IJPharm-53-103-g001.jpg

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