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Harnessing Type I IFN Immunity Against SARS-CoV-2 with Early Administration of IFN-β.

作者信息

Vinh Donald C, Abel Laurent, Bastard Paul, Cheng Matthew P, Condino-Neto Antonio, Gregersen Peter K, Haerynck Filomeen, Cicalese Maria-Pia, Hagin David, Soler-Palacín Pere, Planas Anna M, Pujol Aurora, Notarangelo Luigi D, Zhang Qian, Su Helen C, Casanova Jean-Laurent, Meyts Isabelle

机构信息

McGill University Health Centre, Montreal, Canada.

St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, 10065, USA.

出版信息

J Clin Immunol. 2021 Oct;41(7):1425-1442. doi: 10.1007/s10875-021-01068-6. Epub 2021 Jun 8.

Abstract
摘要

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Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity.
Cell. 2021 Apr 29;184(9):2523. doi: 10.1016/j.cell.2021.04.006.
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Neutralizing Autoantibodies to Type I IFNs in >10% of Patients with Severe COVID-19 Pneumonia Hospitalized in Madrid, Spain.
J Clin Immunol. 2021 Jul;41(5):914-922. doi: 10.1007/s10875-021-01036-0. Epub 2021 Apr 13.
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Autoantibodies against type I interferons are associated with multi-organ failure in COVID-19 patients.
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Viral infections in humans and mice with genetic deficiencies of the type I IFN response pathway.
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