应用共焦显微镜评估慢性阻塞性肺疾病患者的角膜内皮细胞。
Evaluation of the corneal endothelium by specular microscopy in patients with chronic obstructive pulmonary disease.
机构信息
Faculty of Medicine, Department of Ophthalmology, Yozgat Bozok University, Yozgat, Turkey.
Faculty of Medicine, Department of Chest Disease, Yozgat Bozok University, Yozgat, Turkey.
出版信息
Clin Respir J. 2021 Oct;15(10):1056-1062. doi: 10.1111/crj.13408. Epub 2021 Jun 22.
OBJECTIVE
The objective of this study is to evaluate the corneal endothelium in patients with chronic obstructive pulmonary disease (COPD) using a specular microscope.
METHODS
The right eyes of 64 patients with a COPD diagnosis and 65 healthy individuals were evaluated. Cell density (CD) (cell/mm ), corneal thickness (CT) (μ), hexagonal cell ratio (%), and coefficient of variation (cell area standard deviation/mean cell area, μm ) were analyzed by specular microscopy (SM).
RESULTS
The CT was significantly reduced in the COPD group compared with the control group (P = 0.021). Moreover, a significant difference was found between the COPD group and the control group in terms of corneal endothelial CD (P = 0.011), hexagonal cell ratio (P = 0.008), and coefficient of variation (P = 0.012).
CONCLUSION
The corneal endothelial structure was significantly deteriorated in patients with COPD compared with the control group. SM is a valuable method that could be used in treatment and follow-up of corneal endothelium in patients with COPD.
目的
本研究旨在使用角膜内皮镜评估慢性阻塞性肺疾病（COPD）患者的角膜内皮。
方法
评估 64 例 COPD 诊断患者和 65 名健康个体的右眼。通过角膜内皮镜（SM）分析细胞密度（CD）（细胞/平方毫米）、角膜厚度（CT）（μm）、六边形细胞比例（%）和变异系数（细胞面积标准差/平均细胞面积，μm）。
结果
与对照组相比，COPD 组的 CT 明显降低（P=0.021）。此外，COPD 组与对照组在角膜内皮 CD（P=0.011）、六边形细胞比例（P=0.008）和变异系数（P=0.012）方面存在显著差异。
结论
与对照组相比，COPD 患者的角膜内皮结构明显恶化。SM 是一种有价值的方法，可用于 COPD 患者的角膜内皮治疗和随访。
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