Morimoto Mai M, Uchishiba Emi, Saleem Aman B
UCL Institute of Behavioural Neuroscience, Department of Experimental Psychology, University College London, London, WC1H 0AP, UK.
iScience. 2021 Apr 17;24(5):102450. doi: 10.1016/j.isci.2021.102450. eCollection 2021 May 21.
Top-down, context-dependent modulation of visual processing has been a topic of wide interest, including in mouse primary visual cortex (V1). However, the organization of feedback projections to V1 is relatively unknown. Here, we investigated inputs to mouse V1 by injecting retrograde tracers. We developed a software pipeline that maps labeled cell bodies to corresponding brain areas in the Allen Reference Atlas. We identified more than 24 brain areas that provide inputs to V1 and quantified the relative strength of their projections. We also assessed the organization of the projections, based on either the organization of cell bodies in the source area (topography) or the distribution of projections across V1 (bias). Projections from most higher visual and some nonvisual areas to V1 showed both topography and bias. Such organization of feedback projections to V1 suggests that parts of the visual field are differentially modulated by context, which can be ethologically relevant for a navigating animal.
自上而下的、依赖上下文的视觉处理调制一直是一个备受广泛关注的话题，在小鼠初级视觉皮层（V1）中也是如此。然而，向V1的反馈投射的组织情况相对未知。在这里，我们通过注射逆行示踪剂来研究小鼠V1的输入。我们开发了一个软件流程，将标记的细胞体映射到艾伦参考图谱中的相应脑区。我们确定了24多个向V1提供输入的脑区，并量化了它们投射的相对强度。我们还基于源区域中细胞体的组织情况（拓扑结构）或投射在V1上的分布（偏差）来评估投射的组织情况。从大多数高级视觉区域和一些非视觉区域到V1的投射显示出拓扑结构和偏差。这种向V1的反馈投射组织表明，视野的部分区域受到上下文的差异调制，这在行为学上可能与导航动物相关。
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