miRNAs 与鼻咽癌侵袭转移关系的研究进展

Advances in Research on microRNAs Related to the Invasion and Metastasis of Nasopharyngeal Carcinoma.

机构信息

Hunan Province Key Laboratory of Tumor Cellular & Molecular Pathology, Cancer Research Institute, Hengyang School of Medicine, University of South China, Hengyang, Hunan 421001, China.

Department of Oncology hematology, The Second Affiliated Hospital, University of South China, Hengyang, Hunan 421001, China.

出版信息

Curr Mol Pharmacol. 2022;15(3):463-474. doi: 10.2174/1874467214666210614150720.

DOI:10.2174/1874467214666210614150720

PMID:34126919

Abstract

Nasopharyngeal Carcinoma (NPC), which is associated with latent Epstein-Barr virus infection in most cases, is a unique epithelial malignancy arising from the nasopharyngeal mucosal lining. Accumulating evidence is providing insights into the genetic and molecular aberrations that likely drive nasopharyngeal tumor development and progression. We review recent analyses of microRNAs (miRNAs), including Epstein-Barr virus-encoded miRNAs (EBV-encoded miRNAs) and dysregulated cellular miRNAs, that may be related to the metastasis of nasopharyngeal carcinoma. The studies summarized herein have greatly expanded our knowledge of the molecular biology of NPC involving miRNAs, and they may provide new biological targets for clinical diagnosis and reveal the potential of microRNA therapeutics. However, much remains to be uncovered.

摘要

鼻咽癌（NPC）在大多数情况下与潜伏的 Epstein-Barr 病毒感染有关，是一种源自鼻咽黏膜衬里的独特上皮恶性肿瘤。越来越多的证据为我们提供了深入了解遗传和分子异常的机会，这些异常可能推动了鼻咽癌的发展和进展。我们回顾了最近对 microRNAs（miRNAs）的分析，包括 Epstein-Barr 病毒编码的 miRNAs（EBV-encoded miRNAs）和失调的细胞 miRNAs，这些可能与鼻咽癌的转移有关。本文总结的研究极大地扩展了我们对涉及 miRNAs 的 NPC 分子生物学的认识，它们可能为临床诊断提供新的生物学靶点，并揭示了 microRNA 治疗的潜力。然而，仍有许多未解之谜。